[HTML][HTML] Targeting HGF/c-MET axis in pancreatic cancer
Pancreatic cancer (pancreatic ductal adenocarcinoma (PDAC/PC)) has been an aggressive
disease that is associated with early metastases. It is characterized by dense and …
disease that is associated with early metastases. It is characterized by dense and …
[HTML][HTML] Targeting the HGF/c-MET pathway: stromal remodelling in pancreatic cancer
Stromal-tumor interactions in pancreatic cancer (PC) impact on treatment outcomes.
Pancreatic stellate cells (PSCs) produce the collagenous stroma of PC and interact with …
Pancreatic stellate cells (PSCs) produce the collagenous stroma of PC and interact with …
[HTML][HTML] HGF/c-Met pathway inhibition combined with chemotherapy increases cytotoxic T-cell infiltration and inhibits pancreatic tumour growth and metastasis
Pancreatic cancer (PC) is a deadly cancer with a high mortality rate. The unique
characteristics of PC, including desmoplasia and immunosuppression, have made it difficult …
characteristics of PC, including desmoplasia and immunosuppression, have made it difficult …
[HTML][HTML] MET/HGF co-targeting in pancreatic cancer: a tool to provide insight into the tumor/stroma crosstalk
C Modica, D Tortarolo, PM Comoglio… - International journal of …, 2018 - mdpi.com
The 'onco-receptor'MET (Hepatocyte Growth Factor Receptor) is involved in the activation of
the invasive growth program that is essential during embryonic development and critical for …
the invasive growth program that is essential during embryonic development and critical for …
[HTML][HTML] Hepatocyte growth factor from a clinical perspective: A pancreatic cancer challenge
W Rizwani, AE Allen, JG Trevino - Cancers, 2015 - mdpi.com
Pancreatic cancer is the fourth leading cause of cancer-related deaths in the United States
and incidence rates are rising. Both detection and treatment options for pancreatic cancer …
and incidence rates are rising. Both detection and treatment options for pancreatic cancer …
[HTML][HTML] Targeting the HGF/c-MET pathway in advanced pancreatic cancer: A key element of treatment that limits primary tumour growth and eliminates metastasis
Background Stromal–tumour interactions facilitate pancreatic cancer (PC) progression. The
hepatocyte growth factor (HGF)/c-MET pathway is upregulated in PC and mediates the …
hepatocyte growth factor (HGF)/c-MET pathway is upregulated in PC and mediates the …
[HTML][HTML] Hepatocyte growth factor inhibition: a novel therapeutic approach in pancreatic cancer
Background: Pancreatic stellate cells (PSCs, which produce the stroma of pancreatic cancer
(PC)) interact with cancer cells to facilitate PC growth. A candidate growth factor pathway …
(PC)) interact with cancer cells to facilitate PC growth. A candidate growth factor pathway …
Dual inhibition of Hedgehog and c-Met pathways for pancreatic cancer treatment
AA Rucki, Q Xiao, S Muth, J Chen, X Che… - Molecular cancer …, 2017 - AACR
Pancreatic ductal adenocarcinoma (PDAC) is one of the most chemotherapy-and
radiotherapy-resistant tumors. The c-Met and Hedgehog (Hh) pathways have been shown …
radiotherapy-resistant tumors. The c-Met and Hedgehog (Hh) pathways have been shown …
[HTML][HTML] HGF/c-MET axis in tumor microenvironment and metastasis formation
A Spina, V De Pasquale, G Cerulo, P Cocchiaro… - Biomedicines, 2015 - mdpi.com
Tumor metastases are responsible for approximately 90% of all cancer-related deaths.
Metastasis formation is a multistep process that requires acquisition by tumor cells of a …
Metastasis formation is a multistep process that requires acquisition by tumor cells of a …
[HTML][HTML] Extracellular matrix influencing HGF/c-MET signaling pathway: impact on cancer progression
H Noriega-Guerra, VM Freitas - International journal of molecular …, 2018 - mdpi.com
The extracellular matrix (ECM) is a crucial component of the tumor microenvironment
involved in numerous cellular processes that contribute to cancer progression. It is …
involved in numerous cellular processes that contribute to cancer progression. It is …