The Met tyrosine kinase receptor is the only known receptor for hepatocyte growth factor
(HGF). Downstream Met signaling is essential for embryonic development; however …

Hepatocyte growth factor (HGF) is a widely expressed growth factor secreted by cells of
mesenchymal origin, which has been shown to be involved in growth processes of multiple …

Introduction: Pancreatic cancer treatment remains a challenge for clinicians and
researchers. Despite undisputable advances in the comprehension of the molecular …

ABSTRACT C-Myc overexpression is a common finding in pancreatic cancer and predicts
the aggressive behavior of cancer cells. It binds to the promoter of different genes, thereby …

Pancreatic ductal adenocarcinoma (PDAC) is unrivalled the deadliest gastrointestinal
cancer in the western world. There is substantial evidence implying that insulin and insulin …

To test the hypothesis that concomitant targeting of the epidermal growth factor receptor
(EGFR) and transforming growth factor-beta (TGF-β) may offer a novel therapeutic approach …

The poor prognosis of hepatocellular carcinoma (HCC), one of the most devastating cancers
worldwide, is due to frequent recurrence and metastasis. Among the metastatic factors in the …

Pancreatic cancer has become the fourth leading cause of cancer death in the last two
decades. Only 3%-15% of patients diagnosed with pancreatic cancer had 5 year survival …

Pancreatic cancer is associated with a pronounced fibrotic reaction that was recently shown
to limit delivery of chemotherapy. To identify potential therapeutic targets to overcome this …

MET is located on chromosome 7q31 and is a proto-oncogene that encodes for hepatocyte
growth factor (HGF) receptor, a member of the receptor tyrosine kinase (RTK) family. HGF …