Introduction: Under normal conditions, hepatocyte growth factor (HGF)-induced activation of
its cell surface receptor, the Met tyrosine kinase (TK), is tightly regulated by paracrine ligand …

Pancreatic ductal adenocarcinoma (PDAC) is the fourth most common cause of death from
cancer. Its 5-year survival rate is less than 5%. This poor prognosis is mostly due to the …

The signaling mediated by c-MET and its ligand, hepatocyte growth factor (HGF), has been
implicated in malignant progression of cancer involving stimulation of proliferation, invasion …

Hepatocyte growth factor/scatter factor (HGF/SF) is a pleiotropic effector of cells expressing
the Met tyrosine kinase receptor. While HGF/SF-Met signaling clearly plays a role in a variety …

Hepatocyte growth factor (HGF) ligand and its receptor tyrosine kinase (RTK) mesenchymal-
epithelial transition factor (MET) are important regulators of cellular processes such as …

Liver cancer is the sixth most prevalent form of cancer worldwide and the third leading cause
of cancer-related death [1]. Chronic hepatitis due to excessive alcohol intake, autoimmune …

Pancreatic cancer is a disease with remarkably poor patient survival rates. The frequent
presence of metastases and profound chemoresistance pose a severe problem for the …

Pancreatic ductal adenocarcinoma (PDAC), the most common form of pancreatic cancer, is
one of the most lethal human diseases. PDAC is now the fourth leading cause of cancer …

Pancreatic carcinoma cells overexpress the insulin-like growth factor-I (IGF-I) receptor (IGF-
IR) and the hepatocyte growth factor (HGF) receptor, c-Met, which are both known to …

Hepatocyte growth factor (HGF) was discovered in 1984 as a mitogen of rat hepatocytes in a
primary culture system. In the mid-1980s, MET was identified as an oncogenic mutant …