Hepatocyte growth factor (HGF) and Met/HGF receptor tyrosine kinase play a role in the
progression to invasive and metastatic cancers. A variety of cancer cells secrete molecules …

An overactivation of hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor
(MET) axis promotes tumorigenesis and tumor progression in various cancer types …

Functionally, the pancreas consists of two types of tissues: exocrine and endocrine. Exocrine
pancreatic disorders mainly involve acute and chronic pancreatitis. Acute pancreatitis …

Pancreatic cancer (PC) is the utmost stroma-rich cancer, which is accompanied by fibrotic
reactions that stimulate interactions between tumor cells and stroma to promote tumor …

Highlights•Therapies targeting RTKs are a new perspective in the treatment of cancer.•MET,
the tyrosine kinase receptor for HGF, is altered in human tumors.•MET/HGF pathway can be …

Perineural invasion (PNI) is a pathologic feature of pancreatic cancer and is associated with
poor outcomes, metastasis, and recurrence in pancreatic cancer patients. However, the …

Pancreatic cancer is a devastating disease with historically limited success in treatment and
a poor prognosis. Pancreatic cancer appears to have a progressive pathway of …

Under normal conditions, hepatocyte growth factor (HGF)-induced Met tyrosine kinase (TK)
activation is tightly regulated by paracrine ligand delivery, ligand activation at the target cell …

Abstract c-Met is a receptor tyrosine kinase belonging to the MET (MNNG HOS transforming
gene) family, and is expressed on the surfaces of various cells. Hepatocyte growth factor …

Pancreatic stellate cells (PSCs), a pivotal component of the tumor microenvironment,
contribute to tumor growth and metastasis. PSC-derived factors are essential for triggering …