The α/β-heterodimeric transcription factor hypoxia-inducible factor (HIF) functions when the
oxygen level in tissues is low, ie when the tissue microenvironment becomes hypoxic, and is …

At a molecular level, hypoxia induces the stabilization and activation of the α-subunit of an
α/β heterodimeric transcription factor, appropriately termed HIF (hypoxia-inducible factor) …

Could a rational, hypothesis-driven and well-tolerated therapy drive tumor progression? This
scenario can be foreseen for antiangiogenic therapy, despite it is one of the most elegant …

Tumor hypoxia is a feature common to almost all solid tumors due to malformed vasculature
and inadequate perfusion. Tumor cells have evolved mechanisms that allow them to …

Hypoxia-inducible factors (HIFs) are master regulators of oxygen homeostasis that match O2
supply and demand for each of the 50 trillion cells in the adult human body. Cancer cells co …

Hypoxia-inducible factors (HIFs) are essential mediators of the cellular oxygen-signaling
pathway. They are heterodimeric transcription factors consisting of an oxygen-sensitive …

Regions of low oxygen tension are common findings in malignant tumors and are
associated with increased frequency of tumor invasion and metastasis. Indeed, the ability to …

Hypoxia-inducible factor (HIF) is an α, β-heterodimeric transcription factor that mediates
cellular responses to low oxygen concentration via the transcriptional activation of specific …

Decreased oxygen availability is a common feature during embryonic development as well
of malignant tumours. Hypoxia regulates many transcription factors, and one of the most …

Tissue hypoxia occurs where there is an imbalance between oxygen supply and
consumption in both, solid tumors as a result of exponential cellular proliferation and in …