Male sex is a risk factor for colorectal cancer (CRC) with higher illness burden and earlier
onset. Thus, we hypothesized that loss of chromosome Y (LOY) in the tumor micro …

Blockade of inhibitory immune checkpoints (ICs) is a promising therapeutic approach;
however, it has shown limited success in some cancers including colorectal cancer (CRC) …

Background Although age-related loss of chromosome Y (LOY) in normal hematopoietic
cells is a well-known phenomenon, the phenotypic consequences of LOY have been …

Paramount to the efficacy of immune checkpoint inhibitors is proper selection of patients with
adequate tumor immunogenicity and a robust but suppressed immune infiltrate. In colon …

Background Mosaic loss of chromosome Y (LOY) in leukocytes is the most prevalent somatic
aneuploidy in aging humans. Men with LOY have increased risks of all-cause mortality and …

T regulatory cells (Tregs) play different roles in the regulation of anti-tumor immunity in
colorectal cancer (CRC), depending on the presence of different Treg subsets. We …

The existence of various T regulatory cell (Treg) subsets in colorectal cancer (CRC) could
play a variety of functions in the regulation of anti-cancer immunity. We studied correlations …

There are different subsets of T regulatory cells (Tregs), orchestrating critical roles in the
regulation of anti-tumor immunity in colorectal cancer (CRC). In this study, we report that a …

Simple Summary Colorectal cancer is one of the leading causes of global cancer-related
mortality. Tumor-infiltrating effector immune cells play critical roles in tumor control, and their …

Enrichment of regulatory T cells (Tregs) in the tumour microenvironment (TME) has been
recognized as one of the major factors in the initiation and development of resistance to …