HLA-A+ tertiary lymphoid structures with reactivated tumor infiltrating lymphocytes are associated with a positive immunotherapy response in esophageal squamous …
D Zhang, D Jiang, L Jiang, J Ma, X Wang, X Xu… - British Journal of …, 2024 - nature.com
Background Immune checkpoint blockade (ICB) therapy provides remarkable clinical
benefits for multiple cancer types. However, the overall response rate to ICB therapy …
benefits for multiple cancer types. However, the overall response rate to ICB therapy …
[HTML][HTML] Immune cell infiltration-associated signature in colon cancer and its prognostic implications
D Deng, X Luo, S Zhang, Z Xu - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
Tumor immune cell infiltration (ICI) has been reported in various studies to be correlated with
tumor diagnosis, clinical treatment sensitivity and prognosis. It is an important direction to …
tumor diagnosis, clinical treatment sensitivity and prognosis. It is an important direction to …
Targeting m6A reader YTHDF1 augments antitumour immunity and boosts anti-PD-1 efficacy in colorectal cancer
Objective The role of N6-methyladenosine (m6A) in tumour immune microenvironment
(TIME) remains understudied. Here, we elucidate function and mechanism of YTH N6 …
(TIME) remains understudied. Here, we elucidate function and mechanism of YTH N6 …
Deregulated mucosal immune surveillance through gut-associated regulatory T cells and PD-1+ T cells in human colorectal cancer
H Fujimoto, Y Saito, K Ohuchida… - The Journal of …, 2018 - journals.aai.org
Disturbed balance between immune surveillance and tolerance may lead to poor clinical
outcomes in some malignancies. In paired analyses of adenocarcinoma and normal mucosa …
outcomes in some malignancies. In paired analyses of adenocarcinoma and normal mucosa …
Regulatory T-cell-mediated inhibition of antitumor immune responses is associated with clinical outcome in patients with liver metastasis from colorectal cancer
KW Brudvik, K Henjum, EM Aandahl… - Cancer immunology …, 2012 - Springer
Adaptive regulatory T cells (Tregs) contribute to an immunosuppressive microenvironment in
colorectal cancer (CRC). Here, we examined whether the level of Treg-mediated inhibition …
colorectal cancer (CRC). Here, we examined whether the level of Treg-mediated inhibition …
[HTML][HTML] GITR ligation improves anti-PD1-mediated restoration of human MMR-proficient colorectal carcinoma tumor-derived T cells
YS Rakké, LC Carrascosa, AA van Beek… - Cellular and Molecular …, 2023 - Elsevier
Background & Aims In contrast to mismatch repair deficient colorectal carcinoma (CRC),
MMR proficient (pMMR) CRC does not respond to immune checkpoint blockade. We studied …
MMR proficient (pMMR) CRC does not respond to immune checkpoint blockade. We studied …
Distinct tumor microenvironment landscapes of rectal cancer for prognosis and prediction of immunotherapy response
F Bu, Y Zhao, Y Zhao, X Yang, L Sun, Y Chen, S Zhu… - Cellular Oncology, 2022 - Springer
Purpose Tumor microenvironment (TME) affects the progression of rectal cancer (RC), and
the clinical relevance of its immune elements was widely reported. Here we aim to delineate …
the clinical relevance of its immune elements was widely reported. Here we aim to delineate …
[HTML][HTML] Spatially resolved multimarker evaluation of CD274 (PD-L1)/PDCD1 (PD-1) immune checkpoint expression and macrophage polarisation in colorectal cancer
H Elomaa, M Ahtiainen, SA Väyrynen, S Ogino… - British Journal of …, 2023 - nature.com
Abstract Background The CD274 (PD-L1)/PDCD1 (PD-1) immune checkpoint interaction
may promote cancer progression, but the expression patterns and prognostic significance of …
may promote cancer progression, but the expression patterns and prognostic significance of …
[HTML][HTML] Deciphering Treg cell roles in esophageal squamous cell carcinoma: a comprehensive prognostic and immunotherapeutic analysis
P Zhang, S Dong, W Sun, W Zhong… - Frontiers in Molecular …, 2023 - ncbi.nlm.nih.gov
Background: Esophageal squamous cell carcinoma (ESCC) is a prevalent and aggressive
form of cancer that poses significant challenges in terms of prognosis and treatment …
form of cancer that poses significant challenges in terms of prognosis and treatment …
[HTML][HTML] Constructing a tregs-associated signature to predict the prognosis of colorectal cancer patients: a STROBE-compliant retrospective study
G Ping, Y Tian, Z Zhou - Medicine, 2022 - journals.lww.com
Colorectal cancer (CRC) ranks as the second leading cause of cancer-related mortality
worldwide. Regulatory T cells (Tregs) are a key constituent of immune cells in the tumor …
worldwide. Regulatory T cells (Tregs) are a key constituent of immune cells in the tumor …