Introduction Colorectal cancer (CRC) is the third leading cause of cancer-related deaths
globally. Tumour-infiltrating leukocytes play an important role in cancers, including CRC. We …

Simple Summary The poor prognosis outcome of patients with KRAS mutations (KRAS mut)
was correlated with an immunosuppressive tumor microenvironment (TME). At the gene …

Regulatory T cells (Tregs) are a subset of CD4+ T lymphocytes known to dampen the host
immune response against cancer cells. Within the tumor microenvironment, Tregs are potent …

Abstract Background Immune checkpoint inhibitors (ICIs) have revolutionized the cancer
therapeutic landscape and our perception of interactions between the immune system and …

Tertiary lymphoid structure (TLS) contributes to the anti-tumor immune response, and
predicts the prognosis of colorectal cancer patients. However, the potential impact of TLS in …

Colorectal cancer (CRC) is one of the most prevalent cancer types worldwide, with a high
mortality rate due to metastasis. The tumor microenvironment (TME) contains multiple …

Checkpoint inhibitors target the inhibitory receptors expressed by tumor-infiltrating T cells in
order to reinvigorate an anti-tumor immune response. Therefore, understanding T cell …

The frequency of circulating or tumour‐infiltrating regulatory T cells (Tregs) has been
associated with poor patient survival in many cancers including breast, melanoma and lung …

Background Biomarkers based on immune context may guide prognosis prediction. T-cell
inactivation, exclusion, or dysfunction could cause unfavorable tumor microenvironments …

Epidemiological investigations show that mosaic loss of chromosome Y (LOY) in leukocytes
is associated with earlier mortality and morbidity from many diseases in men. LOY is the …