[HTML][HTML] The E3 Ligase TRIM25 Impairs Apoptotic Cell Death in Colon Carcinoma Cells via Destabilization of Caspase-7 mRNA: A Possible Role of hnRNPH1
U Nasrullah, K Stanke, V Recknagel, S Bozkurt… - Cells, 2023 - mdpi.com
Therapy resistance is still a major reason for treatment failure in colorectal cancer (CRC).
Previously, we identified the E3 ubiquitin ligase TRIM25 as a novel suppressor of caspase-2 …
Previously, we identified the E3 ubiquitin ligase TRIM25 as a novel suppressor of caspase-2 …
[HTML][HTML] Identification of TRIM25 as a negative regulator of caspase-2 expression reveals a novel target for sensitizing colon carcinoma cells to intrinsic apoptosis
U Nasrullah, K Haeussler, A Biyanee, I Wittig… - Cells, 2019 - mdpi.com
Colorectal cancer (CRC) is one of the most common cancers that is characterized by a high
mortality due to the strong metastatic potential of the primary tumor and the high rate of …
mortality due to the strong metastatic potential of the primary tumor and the high rate of …
[HTML][HTML] Knockdown of tripartite motif containing 24 by lentivirus suppresses cell growth and induces apoptosis in human colorectal cancer cells
J Wang, J Zhu, M Dong, H Yu, X Dai, K Li - Oncology Research, 2014 - ncbi.nlm.nih.gov
Colorectal cancer remains one of the most common cancers in men and women, and it
accounts for a large proportion of cancer-related deaths worldwide. Tripartite motif (TRIM) …
accounts for a large proportion of cancer-related deaths worldwide. Tripartite motif (TRIM) …
[HTML][HTML] TRIM32 protein sensitizes cells to tumor necrosis factor (TNFα)-induced apoptosis via its RING domain-dependent E3 ligase activity against X-linked inhibitor …
YS Ryu, Y Lee, KW Lee, CY Hwang, JS Maeng… - Journal of Biological …, 2011 - ASBMB
TRIM32, which belongs to the tripartite motif (TRIM) protein family, has the RING finger, B-
box, and coiled-coil domain structures common to this protein family, along with an …
box, and coiled-coil domain structures common to this protein family, along with an …
[HTML][HTML] Overexpression of E3 ubiquitin ligase tripartite motif 32 correlates with a poor prognosis in patients with gastric cancer
M Ito, K Migita, S Matsumoto… - Oncology …, 2017 - spandidos-publications.com
Tripartite motif protein (TRIM) 32 belongs to the TRIM family, which is composed of RING
finger, B‑box and coiled‑coil domains. TRIM32 has been reported to function as an enzyme …
finger, B‑box and coiled‑coil domains. TRIM32 has been reported to function as an enzyme …
[HTML][HTML] Dual roles of TRIM3 in colorectal cancer by retaining p53 in the cytoplasm to decrease its nuclear expression
Y Han, S Lu, C Song, Y Xuan, M Zhang, H Cai - Cell Death Discovery, 2023 - nature.com
Colorectal cancer is a very heterogeneous disease caused by the interaction of genetic and
environmental factors. P53, as a frequent mutation gene, plays a critical role in the adenoma …
environmental factors. P53, as a frequent mutation gene, plays a critical role in the adenoma …
TRIM24 is critical for the cellular response to DNA double-strand breaks through regulating the recruitment of MRN complex
Y Wang, Y Yao, Q Wei, S Long, Y Chen, J Xie, R Tan… - Oncogene, 2023 - nature.com
Abstract The MRE11-RAD50-NBS1 (MRN) complex plays a crucial role in DNA double-
strand breaks (DSBs) sensing and initiation of signaling cascades. However, the precise …
strand breaks (DSBs) sensing and initiation of signaling cascades. However, the precise …
Tripartite motif-containing protein 26 promotes colorectal cancer growth by inactivating p53
H Lu, Z Tan, H Ko, P Naji, R Zhu, J Wang, S Huang… - 2024 - researchsquare.com
Tripartite motif-containing protein 26 (TRIM26) is an E3 ubiquitin ligase that exhibits
divergent roles in various cancer types (oncogenic and anti-oncogenic). This study …
divergent roles in various cancer types (oncogenic and anti-oncogenic). This study …
[HTML][HTML] TRIM58 functions as a tumor suppressor in colorectal cancer by promoting RECQL4 ubiquitination to inhibit the AKT signaling pathway
N Sun, J Shen, Y Shi, B Liu, S Gao, Y Chen… - World Journal of Surgical …, 2023 - Springer
Background This study aimed to investigate the underlying molecular mechanisms of
TRIM58 in the development of colorectal cancer (CRC). CRC is one of the most common …
TRIM58 in the development of colorectal cancer (CRC). CRC is one of the most common …
TRIM55 inhibits colorectal cancer development via enhancing protein degradation of c‐Myc
M Lin, Z Fang, X Lin, W Zhou, Y Wang, S Han… - Cancer …, 2023 - Wiley Online Library
Background Colorectal cancer (CRC) is one of the most common and lethal malignancies
which including colon and rectum cancer. Tripartite motif containing 55 (TRIM55) is an E3 …
which including colon and rectum cancer. Tripartite motif containing 55 (TRIM55) is an E3 …