Albumin, a major plasma protein with extraordinary ligand binding properties, transports
various ligands ranging from drugs, hormones, fatty acids, and toxins to different tissues and …

Diabetes mellitus is one of the most serious diseases in the world. The levels of glycated
proteins in the blood of diabetics are higher than that of non-diabetic subjects. The glycation …

The extraordinary ligand binding properties of albumin makes it a key player in the
pharmacokinetics and pharmacodynamics of many vital drugs. Albumin is highly susceptible …

Oxidative stress and protein modifications are frequently observed in numerous disease
states. Glucose constitutes a vital nutrient necessary to cellular oxygen metabolism …

BACKGROUND: Serum protein glycation and formation of advanced glycation endproducts
(AGE) correlates with diabetic complications. Highly AGE-modified albumin is frequently …

Early glycation involves attachment of glucose on ε-NH2 of lysine residues. Human serum
albumin (HSA), a lysine rich protein, is highly prone to non-enzymatic glycation. In this study …

Albumin, the major circulating protein in blood plasma, can be subjected to an increased
level of glycation in a diabetic context. Albumin exerts crucial pharmacological activities …

Albumin glycation and subsequent formation of advanced glycation end products (AGEs)
correlate with diabetes and associated complications. Human Serum Albumin (HSA) was …

Aim Non-enzymatic glycation impairs the structural and functional characterstics of human
serum albumin (HSA) native conformation. Prolonged hyperglycemia causes cross links …

We monitored the unfolding of human serum albumin (HSA) and glycated human serum
albumin (gHSA) subjected to guanidine hydrochloride (GndHCl) by using fluorescence and …