Gut inflammation or injury causes intestinal hypersensitivity (IHS) and hyperalgesia, which
can persist after the initiating pathology resolves, are often referred to somatic regions and …

Chronic abdominal pain accompanying intestinal inflammation emerges from the
hyperresponsiveness of neuronal, immune and endocrine signaling pathways within the …

The high comorbidity existing between visceral pain and psychiatric disorders such as
depression and anxiety is well documented and it is gaining increasing interest among …

Visceral pain following infection or inflammation is a major clinical problem. Although we
have knowledge of how peripheral endings of colonic afferents change in disease, their …

Functional gastrointestinal disorders are commonly encountered in clinical practice, and
pain is their commonest presenting symptom. In addition, patients with these disorders often …

Visceral pain arising from inner organs differs from somatic pain in crucial aspects, limiting
the possibility to transfer knowledge derived from somatic pain research. The …

A dual action of stress on pain modulation has been well characterized in the somatic pain
studies, while much less is known in the visceral field. In the context of clinical observations …

Over the past decade, attention has been paid to the role of visceral sensitivity in the
pathophysiology of functional bowel disorders, especially irritable bowel syndrome, and …

Chronic abdominal pain is a common symptom of great clinical significance in several areas
of medicine. In many cases no organic cause can be established resulting in the …

Neural plasticity is not only the adaptive response of the central nervous system to learning,
structural damage or sensory deprivation, but also an increasingly recognized common …