Familial British dementia and familial Danish dementia are neurodegenerative disorders
caused by mutations in the gene integral membrane protein 2B (ITM2b) encoding BRI2 …

An autosomal dominant mutation in the BRI2/ITM2B gene causes familial Danish dementia
(FDD). Analysis of FDDKI mice, a mouse model of FDD genetically congruous to the human …

Mutations in integral membrane protein 2B (ITM2b/BRI2) gene cause familial British and
Danish dementia (FBD and FDD), autosomal dominant disorders characterized by …

Familial British Dementia (FBD) is caused by an autosomal dominant mutation in the
BRI2/ITM2B gene. FBDKI mice are a model of FBD that is genetically congruous to the …

Mutations in the Integral membrane protein 2B (ITM2b/BRI2) gene, which codes for a protein
called BRI2, cause familial British and Danish dementia (FBD and FDD). Loss of BRI2 …

Analyses of the biologic effects of mutations in the BRI2 (ITM2b) and the amyloid β precursor
protein (APP) genes support the hypothesis that cerebral accumulation of amyloidogenic …

An autosomal dominant mutation in the BRI2/ITM2B gene causes Familial Danish Dementia
(FDD). We have generated a mouse model of FDD, called FDD KI, genetically congruous to …

In Alzheimer's disease the amyloid β-peptide (Aβ) aggregates in brain tissue and arteries.
Aβ is proteolytically cleaved out from amyloid precursor protein (APP) by different …

Alzheimer disease (AD), the most common senile dementia, is characterized by amyloid
plaques, vascular amyloid, neurofibrillary tangles, and progressive neurodegeneration …

Abstract Alzheimer's disease (AD), the most common form of dementia, shares clinical and
pathological similarities with familial British and Danish dementias (FBD and FDD). Whereas …