Alzheimer's disease (AD) is a progressive neurodegenerative disease caused by
accumulations of Aβ peptides. Production and fibrillation of Aβ are downregulated by BRI2 …

Amyloid molecules harboring pyroglutamate (pGlu) residue at the N-termini are considered
to be important for the development of cerebral amyloidosis such as Alzheimer's disease …

Background: Microglial dysfunction plays a causative role in Alzheimer's disease (AD)
pathogenesis. Here we focus on a germline insertion/deletion variant mapping SIRPß1, a …

Overexpression of amyloid precursor protein (APP), as well as mutations in the APP and
presenilin genes, causes rare forms of Alzheimer's disease (AD). These genetic changes …

A number of human neurodegenerative diseases involve aggregated amyloid proteins in the
brain, eg Alzheimer's disease (β-amyloid) and Parkinson's disease (α-synuclein). Other …

Familial British dementia (FBD) is a disorder characterized by the presence of amyloid
deposits in cerebral blood vessels and brain parenchyma coexisting with neurofibrillary …

Protein misfolding and aggregation is increasingly being recognized as a cause of disease.
In Alzheimer's disease the amyloid-β peptide (Aβ) misfolds into neurotoxic oligomers and …

BRI2, a protein mutated in Familial British and Familial Danish Dementias, interacts with
Amyloid Precursor Protein (APP) and reduces the levels of secreted APPβ (sAPPβ), which …

The genetic lesion underlying familial British dementia (FBD), an autosomal dominant
neurodegenerative disorder, is a T–A transversion at the termination codon of the BRI gene …

Familial British dementia (FBD) is an autosomal dominant neurodegenerative disorder, with
biochemical and pathological similarities to Alzheimer's disease. FBD is associated with a …