Abstract Islet-brain1 (IB1) or c-Jun NH2 terminal kinase interacting protein-1 (JIP-1), the
product of the MAPK8IP1 gene, functions as a neuronal scaffold protein to allow signalling …

Familial British dementia (FBD) is a rare neurodegenerative disorder and shares features
with Alzheimer's disease, including amyloid plaque deposits, neurofibrillary tangles …

Soluble amyloid-β-protein (Aβ) oligomers, a major hallmark of AD, trigger the integrated
stress response (ISR) via multiple pathologies including neuronal hyperactivation …

A PIR-fect storm | Nature Reviews Neuroscience Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

The ubiquitously expressed TAR DNA-binding protein-43 (TDP-43), involved in transcription
and alternative splicing, is a major disease protein in frontotemporal lobar degeneration and …

Familial Danish dementia (FDD), also known as heredopathia ophthalmo-oto-encephalica,
is an autosomal dominant disorder characterized by cataracts, deafness, progressive ataxia …

The BRICHOS domain is found in human precursor proteins associated with cancer,
dementia (Bri2) and amyloid lung disease (proSP-C). Recombinant human (rh) proSP-C …

Familial British dementia, a rare autosomal dominant neurodegenerative disorder, shares
features with Alzheimer's disease, including amyloid plaque deposits, neurofibrillary tangles …

Aggregation of the amyloid-β peptide (Aβ) into toxic oligomers and amyloid fibrils is linked to
the development of Alzheimer's disease (AD). Mutations of the BRICHOS chaperone domain …

This chapter contains sections titled: Introduction FBD and FDD A Novel Gene BRI2 BRI2
Mutations Generate Two New Amyloid Subunits, ABri and ADan Biochemical Properties of …