Cocaine's main pharmacological actions are the inhibition of the dopamine, serotonin, and
norepinephrine transporters. Its main behavioral effects are reward and locomotor …

In previous studies, we generated knock-in mice with a cocaine-insensitive dopamine
transporter (DAT-CI mice) and found cocaine does not stimulate locomotion or produce …

Cocaine addiction is a worldwide public health problem for which there are no established
treatments. The dopamine transporter (DAT) is suspected as the primary target mediating …

There are three known high-affinity targets for cocaine: the dopamine transporter (DAT), the
serotonin transporter (SERT), and the norepinephrine transporter (NET). Decades of studies …

We have previously reported that knockin mice with a cocaine-insensitive dopamine
transporter (DAT-CI mice) do not experience cocaine reward, as measured by conditioned …

Background The dopamine transporter (DAT) plays a critical role in regulating dopamine
neurotransmission. Variations in DAT or changes in basal dopaminergic tone have been …

The plasma membrane dopamine transporter (DAT) is responsible for clearing dopamine
from the synapse. Cocaine blockade of DAT leads to increased extracellular dopamine, an …

Cocaine blocks uptake by neuronal plasma membrane transporters for dopamine (DAT),
serotonin (SERT), and norepinephrine (NET). Cocaine reward/reinforcement has been …

Cocaine produces its reinforcing effects primarily by inhibiting the dopamine transporter
(DAT) at the level of presynaptic terminals and increasing extracellular levels of dopamine …

The behavioral effects of cocaine are affected by gene knockout (KO) of the dopamine
transporter (DAT), the serotonin transporter (SERT) and the norepinephrine transporter …