Scoparone is known to have a wide range of pharmacological properties in vitro. However,
the roles of scoparone in immediate-type allergic reactions have not yet been investigated …

Complementary and alternative medicines are considered as a promising direction for the
development of anti-allergic therapies in oriental countries. We screened approximately 100 …

Mast cells (MCs) are important therapeutic targets for allergic diseases. High‐affinity
immunoglobulin E (IgE) Fc receptors (FcεRI) trigger abnormal activation of MCs. Allergic …

Roxatidine is an active metabolite of roxatidine acetate hydrochloride which is a histamine
H2-receptor antagonist that is used to treat gastric and duodenal ulcers. In this study, we …

Mast cells are an important component of immune responses. Immunoglobulin (Ig) E-
sensitized mast cells release substances within minutes of allergen exposure, triggering …

Introduction Asthma is a chronic and recurring airway disease, which related to mast cell
activation. Many compounds derived from Chinese herbal medicine has promising effects …

Immediate-type hypersensitivity is involved in many allergic diseases such as asthma,
allergic rhinitis and anaphylaxis. The discovery of drugs for the treatment of allergic disease …

Background Complementary and alternative herbal medicines are recently considered as a
promising approach for treating various diseases. We screened approximately 100 plant …

Allergic inflammatory disease such as food allergy, asthma and atopic dermatitis are
increasing worldwide. In this study, we investigated the effect of water extract of Sparassis …

Asthma is a heterogeneous disease related to numerous inflammatory cells, among which
mast cells play an important role in the early stages of asthma. Therefore, treatment of …