[HTML][HTML] Kinetic competition between RNA Polymerase II and Sen1-dependent transcription termination
DZ Hazelbaker, S Marquardt, W Wlotzka, S Buratowski - Molecular cell, 2013 - cell.com
The essential helicase-like protein Sen1 mediates termination of RNA Polymerase II (Pol II)
transcription at snoRNAs and other noncoding RNAs in yeast. A mutation in the Pol II …
transcription at snoRNAs and other noncoding RNAs in yeast. A mutation in the Pol II …
A bacterial-like mechanism for transcription termination by the Sen1p helicase in budding yeast
O Porrua, D Libri - Nature structural & molecular biology, 2013 - nature.com
Transcription termination is essential to generate functional RNAs and to prevent disruptive
polymerase collisions resulting from concurrent transcription. The yeast Sen1p helicase is …
polymerase collisions resulting from concurrent transcription. The yeast Sen1p helicase is …
Termination of non‐coding transcription in yeast relies on both an RNA Pol II CTD interaction domain and a CTD‐mimicking region in Sen1
Z Han, O Jasnovidova, N Haidara, A Tudek… - The EMBO …, 2020 - embopress.org
Pervasive transcription is a widespread phenomenon leading to the production of a plethora
of non‐coding RNA s (nc RNA s) without apparent function. Pervasive transcription poses a …
of non‐coding RNA s (nc RNA s) without apparent function. Pervasive transcription poses a …
[HTML][HTML] Distinct pathways for snoRNA and mRNA termination
Transcription termination at mRNA genes is linked to polyadenylation. Cleavage at the poly
(A) site generates an entry point for the Rat1/Xrn2 exonuclease, which degrades the …
(A) site generates an entry point for the Rat1/Xrn2 exonuclease, which degrades the …
Biochemical characterization of the helicase Sen1 provides new insights into the mechanisms of non-coding transcription termination
Pervasive transcription is widespread and needs to be controlled in order to avoid
interference with gene expression. In Saccharomyces cerevisiae, the highly conserved …
interference with gene expression. In Saccharomyces cerevisiae, the highly conserved …
[HTML][HTML] Cell-cycle modulation of transcription termination factor Sen1
Many non-coding transcripts (ncRNA) generated by RNA polymerase II in S. cerevisiae are
terminated by the Nrd1-Nab3-Sen1 complex. However, Sen1 helicase levels are …
terminated by the Nrd1-Nab3-Sen1 complex. However, Sen1 helicase levels are …
Unravelling the means to an end: RNA polymerase II transcription termination
JN Kuehner, EL Pearson, C Moore - Nature reviews Molecular cell …, 2011 - nature.com
The pervasiveness of RNA synthesis in eukaryotes is largely the result of RNA polymerase II
(Pol II)-mediated transcription, and termination of its activity is necessary to partition the …
(Pol II)-mediated transcription, and termination of its activity is necessary to partition the …
[HTML][HTML] Saccharomyces cerevisiae Sen1 Helicase Domain Exhibits 5′-to 3′-Helicase Activity with a Preference for Translocation on DNA Rather than RNA*♦
S Martin-Tumasz, DA Brow - Journal of Biological Chemistry, 2015 - ASBMB
In the yeast Saccharomyces cerevisiae, the essential nuclear helicase Sen1 is required for
efficient termination of transcription of short noncoding RNA genes by RNA polymerase II …
efficient termination of transcription of short noncoding RNA genes by RNA polymerase II …
Budding yeast RNA polymerases I and II employ parallel mechanisms of transcriptional termination
J Kawauchi, H Mischo, P Braglia… - Genes & …, 2008 - genesdev.cshlp.org
Both RNA polymerase I and II (Pol I and Pol II) in budding yeast employ a functionally
homologous “torpedo-like” mechanism to promote transcriptional termination. For two well …
homologous “torpedo-like” mechanism to promote transcriptional termination. For two well …
cis-and trans-Acting determinants of transcription termination by yeast RNA polymerase II
EJ Steinmetz, SBH Ng, JP Cloute… - Molecular and cellular …, 2006 - Am Soc Microbiol
Most eukaryotic genes are transcribed by RNA polymerase II (Pol II), including those that
produce mRNAs and many noncoding functional RNAs. Proper expression of these genes …
produce mRNAs and many noncoding functional RNAs. Proper expression of these genes …