The essential helicase-like protein Sen1 mediates termination of RNA Polymerase II (Pol II)
transcription at snoRNAs and other noncoding RNAs in yeast. A mutation in the Pol II …

Transcription termination is essential to generate functional RNAs and to prevent disruptive
polymerase collisions resulting from concurrent transcription. The yeast Sen1p helicase is …

Pervasive transcription is a widespread phenomenon leading to the production of a plethora
of non‐coding RNA s (nc RNA s) without apparent function. Pervasive transcription poses a …

Transcription termination at mRNA genes is linked to polyadenylation. Cleavage at the poly
(A) site generates an entry point for the Rat1/Xrn2 exonuclease, which degrades the …

Pervasive transcription is widespread and needs to be controlled in order to avoid
interference with gene expression. In Saccharomyces cerevisiae, the highly conserved …

Many non-coding transcripts (ncRNA) generated by RNA polymerase II in S. cerevisiae are
terminated by the Nrd1-Nab3-Sen1 complex. However, Sen1 helicase levels are …

The pervasiveness of RNA synthesis in eukaryotes is largely the result of RNA polymerase II
(Pol II)-mediated transcription, and termination of its activity is necessary to partition the …

In the yeast Saccharomyces cerevisiae, the essential nuclear helicase Sen1 is required for
efficient termination of transcription of short noncoding RNA genes by RNA polymerase II …

Both RNA polymerase I and II (Pol I and Pol II) in budding yeast employ a functionally
homologous “torpedo-like” mechanism to promote transcriptional termination. For two well …

Most eukaryotic genes are transcribed by RNA polymerase II (Pol II), including those that
produce mRNAs and many noncoding functional RNAs. Proper expression of these genes …