Background and aim Sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase 2 (SERCA2) is
critical in maintaining Ca 2+ homeostasis. The cysteine 674 (C674) is the key redox …

Introduction: The kidney is crucial in the regulation of sodium homeostasis and blood
pressure (BP). Enhancement of Na+/K+-ATPase (NKA) activity in the kidney reduces urine …

Background and Purpose The kidney is essential in regulating sodium homeostasis and BP.
The irreversible oxidation of Cys674 (C674) in the sarcoplasmic/endoplasmic reticulum …

Despite advances in cardioprotection, new therapeutic strategies capable of preventing
ischemia-reperfusion injury of patients are still needed. Here, we discover that sarcoplasmic …

The dopamine D2 receptor (D2R) decreases renal reactive oxygen species (ROS)
production and regulates blood pressure, in part, via positive regulation of paraoxonase 2 …

Background: SERCA [sarco (endo) plasmic reticulum calcium ATPase] is regulated by
oxidative posttranslational modifications at cysteine 674 (C674). Because sarcoplasmic …

Reduced sarco (endo) plasmic reticulum (SR) Ca2+ ATPase (SERCA2) contributes to the
impaired cardiomyocyte Ca2+ homeostasis observed in heart failure. We hypothesized that …

Ca+ mishandling due to impaired activity of cardiac sarco (endo) plasmic reticulum Ca2+
ATPase (SERCA2a) has been associated with the development of left ventricular diastolic …

Reduced cardiomyocyte excitation–contraction coupling and downregulation of the
SERCA2a (sarcoendoplasmic reticulum calcium ATPase 2a) is associated with heart failure …

The Sarco (endo) plasmic reticulum Ca2+ ATPase (SERCA) actively pumps Ca2+ into the
sarco/endoplasmic reticulum, thereby regulating intracellular Ca2+ concentrations and …