Tachykinins act as neurotransmitters and neuromodulators in the central and peripheral
nervous system. Preclinical studies and clinical trials showed that inhibition of the tachykinin …

Background Tachykinins (TK s) are a family of endogenous peptides widely expressed in
the central and in the peripheral nervous systems as well as in the gastrointestinal (GI) tract …

Background Neurokinin receptors may play an important role in the visceral hypersensitivity
and exaggerated motor/secretory activity associated with diarrhoea‐predominant irritable …

Background Tachykinins have been implicated in the pathophysiology of IBS with diarrhoea
(IBS-D). Our aim was to study the efficacy and safety of ibodutant, a selective neurokinin-2 …

Tachykinins (TKs) are abundantly expressed in the gastrointestinal (GI) tract in intrinsic
excitatory motor neurons, interneurons, sensory neurons and extrinsic sensory neurons …

We attempted to establish and validate an in vivo pharmacodynamic (PD) rabbit model to
screen tachykinin NK 2 receptor (NK 2-R) antagonists using pharmacological and …

Irritable bowel syndrome (IBS) is a common disorder mainly characterized by altered bowel
habits and visceral pain. In this study, we investigated the role of tachykinin NK1 receptors in …

Tachykinins (TKs) and their receptors (NK1, NK2 and NK3), which are diffusely expressed in
the human gastrointestinal tract, represent an endogenous modulator system regulating …

Tachykinin NK2 receptors are expressed in the gastrointestinal tract of both laboratory
animals and humans. Experimental data indicate a role for these receptors in the regulation …

Ibodutant (MEN15596,[1-(2-phenyl-1 R-{[1-(tetrahydropyran-4-ylmethyl)-piperidin-4-
ylmethyl]-carbamoyl}-ethylcarbamoyl)-cyclopentyl]-amide) is a tachykinin NK2 receptor …