Bacterial infection of the kidney is associated with renal tubule dysfunction and
dysregulation of systemic electrolyte balance. Whether bacterial molecules directly affect …

Bacterial infection and sepsis are associated with renal tubule dysfunction and
dysregulation of systemic electrolyte balance but the underlying mechanisms are …

Sepsis and endotoxemia induce defects in renal tubule function, but the mechanisms are
poorly understood. Recently, we demonstrated that lipopolysaccharide (LPS) inhibits …

Sepsis is associated with defects in renal tubule function, but the underlying mechanisms
are incompletely understood. Recently, we demonstrated that Gram-negative bacterial …

Previously we demonstrated that basolateral LPS inhibits HCO 3− absorption in the renal
medullary thick ascending limb (MTAL) through TLR4-dependent ERK activation. Here we …

Monophosphoryl lipid A (MPLA) is a detoxified derivative of LPS that induces tolerance to
LPS and augments host resistance to bacterial infections. Previously, we demonstrated that …

Uropathogenic Escherichia coli (UPEC) are the most frequent causes of urinary tract
infections and pyelonephritis. Renal medullary collecting duct (MCD) cells are the intrarenal …

Nephrogenic diabetes insipidus (NDI) is the most common renal side effect in patients
undergoing lithium therapy for bipolar affective disorders. Approximately 2 million US …

Sepsis-associated acute renal failure is characterized by decreased GFR and tubular
dysfunction. The pathogenesis of endotoxemic tubular dysfunction with failure in urine …

Acute renal failure (ARF) induces tubular hyperresponsiveness to TLR4 ligands, culminating
in exaggerated renal cytokine/chemokine production. However, the fate of TLR4 protein …