Reproductive capacity in women starts to decline beyond their mid-30s and pregnancies in
older women result in higher rates of miscarriage with aneuploidy. Age-related decline in …

With extended periods of time following ovulation, the metaphase II stage oocyte
experiences deterioration in quality referred to as post-ovulatory oocyte ageing. Post …

In a healthy body, reactive oxygen species (ROS) and antioxidants remain balanced. When
the balance is broken toward an overabundance of ROS, oxidative stress appears and may …

In their midthirties, women experience a decline in fertility, coupled to a pronounced
increase in the risk of aneuploidy, miscarriage, and birth defects. Although the aetiology of …

In recent years, postponement of marriage and childbearing in women of reproductive age
has led to an increase in the incidence of age-related infertility. The reproductive aging …

Female aging is one of the most important factors that impacts human reproduction. With
aging, there is a natural decline in female fertility. The decrease in fertility is slow and steady …

Mammalian oocytes are long-lived cells in the human body. They initiate meiosis already in
the embryonic ovary, arrest meiotically for long periods in dictyate stage, and resume …

Ovarian aging in women correlates with the progressive loss of both the number and quality
of oocytes. When these processes occur early or are accelerated, their clinical correlates are …

Normal levels of reactive oxygen species (ROS) play an important role in regulating follicular
growth, angiogenesis and sex hormone synthesis in ovarian tissue. When the balance …

Purpose The number of women attempting to conceive between the ages of 36 and 44 has
increased significantly in the last decade. While it is well established that women's …