Mitochondria are fundamental organelles in eukaryotic cells that provide ATP through
oxidative phosphorylation. During this process, reactive oxygen species (ROS) are …

Ovarian aging leads to a decrease in the quantity and quality of oocytes. Aged oocytes have
significantly reduced amounts of mitochondria, the energy factories of cells, leading to lower …

Mitochondrial dysfunction is one of the hallmarks of aging. Consistently mitochondrial DNA
(mtDNA) copy number and function decline with age in various tissues. There is increasing …

The oocyte is the major determinant of embryo developmental competence in women. It
delivers half the chromosomal complement to the embryo, but the maternal and paternal …

Mitochondria, fundamental organelles in cell metabolism, and ATP synthesis are
responsible for generating reactive oxygen species (ROS), calcium homeostasis, and cell …

Human female fertility and reproductive lifespan decrease significantly with age, resulting in
an extended post-reproductive period. The central dogma in human female reproduction …

Purpose Childbearing delay contributes to the increase of subfertile couples that require
assisted reproductive technology (ART). Subfertility relates with reproductive aging (RA). In …

STUDY QUESTION Do the extreme conditions of vitrification affect mitochondrial health and
reactive oxygen species (ROS) levels of human oocytes? SUMMARY ANSWER Vitrification …

BACKGROUND Highly reactive carbonyl compounds formed during glycolysis, such as
methylglyoxal (MG), can lead to the formation of 'advanced glycation end products'(AGE) …

The ovarian system comprises vital organs in females and is of great significance for the
maintenance of reproductive potential and endocrine stability. Although complex …