Myelin basic protein (MBP) is one of the key proteins in the development of multiple
sclerosis (MS). However, very few intracellular MBP partners have been identified up to now …

Myelin basic protein (MBP) is the second most abundant protein in the central nervous
system and is responsible for structural maintenance of the myelin sheath covering axons …

Protein misfolding and aggregation is increasingly being recognized as a cause of disease.
In Alzheimer's disease the amyloid-β peptide (Aβ) misfolds into neurotoxic oligomers and …

Molecular chaperones assist proteins in achieving a functional structure and prevent them
from misfolding into aggregates, including disease-associated deposits. The BRICHOS …

Proteins can misfold into fibrillar or amorphous aggregates and molecular chaperones act
as crucial guardians against these undesirable processes. The BRICHOS chaperone …

Familial British dementia and familial Danish dementia are neurodegenerative disorders
caused by mutations in the gene integral membrane protein 2B (ITM2b) encoding BRI2 …

Mutations in integral membrane protein 2B (ITM2b/BRI2) gene cause familial British and
Danish dementia (FBD and FDD), autosomal dominant disorders characterized by …

Analyses of the biologic effects of mutations in the BRI2 (ITM2b) and the amyloid β precursor
protein (APP) genes support the hypothesis that cerebral accumulation of amyloidogenic …

Molecular chaperones play important roles in preventing protein misfolding and its
potentially harmful consequences. Deterioration of molecular chaperone systems upon …

In Alzheimer's disease the amyloid β-peptide (Aβ) aggregates in brain tissue and arteries.
Aβ is proteolytically cleaved out from amyloid precursor protein (APP) by different …