[HTML][HTML] Flavonoids from Scutellaria amoena CH Wright alleviate mitochondrial dysfunction and regulate oxidative stress via Keap1/Nrf2/HO-1 axis in rats with high-fat …

QL Fang, X Qiao, X Yin, Y Zeng, C Du, Y Xue… - Biomedicine & …, 2023 - Elsevier
Background Nonalcoholic steatohepatitis (NASH) is among the most common liver diseases
in the world. Flavonoids from Scutellaria amoena (SAF) are used in the treatment of …

Protective effects of scutellaria-coptis herb couple against non-alcoholic steatohepatitis via activating NRF2 and FXR pathways in vivo and in vitro

Y Xue, Y Wei, L Cao, M Shi, J Sheng, Q Xiao… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Scutellaria-coptis herb couple (SC) is a classic herbal pair
used in many Traditional Chinese Medicine (TCM) formulations in the treatment of …

Baicalin attenuates non-alcoholic steatohepatitis by suppressing key regulators of lipid metabolism, inflammation and fibrosis in mice

J Zhang, H Zhang, X Deng, N Zhang, B Liu, S Xin, G Li… - Life sciences, 2018 - Elsevier
Aims Baicalin (BA), an active flavonoid compound originating from the herb of Scutellaria
baicalensis Georgi, has been previously shown to exert anti-inflammation and anti-oxidant …

Extracts of vine tea improve diet-induced non-alcoholic steatohepatitis through AMPK-LXRα signaling

Y Chen, H Song, Z Zhang, Q Chen, Z Tang… - Frontiers in …, 2021 - frontiersin.org
Chinese vine tea can improve glucose and lipid metabolic disorders. However, its protective
effects in non-alcoholic steatohepatitis (NASH) and its underlying molecular mechanisms …

Baicalin improved hepatic injury of NASH by regulating NRF2/HO-1/NRLP3 pathway

H Shi, F Qiao, W Lu, K Huang, Y Wen, L Ye… - European journal of …, 2022 - Elsevier
Being at the important pathological stage and the critical treatment period of non-alcoholic
fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH) which is associated with …

Shenling Baizhu powder alleviates non-alcoholic fatty liver disease by modulating autophagy and energy metabolism in high-fat diet-induced rats

M Pan, Y Deng, Y Qiu, D Pi, C Zheng, Z Liang, J Zhen… - Phytomedicine, 2024 - Elsevier
Background Non-alcoholic fatty liver disease (NAFLD) has emerged as a burgeoning health
problem worldwide, but no specific drug has been approved for its treatment. Shenling …

Scutellarin ameliorates nonalcoholic fatty liver disease through the PPARγ/PGC-1α-Nrf2 pathway

X Zhang, R Ji, H Sun, J Peng, X Ma… - Free Radical …, 2018 - Taylor & Francis
Nonalcoholic fatty liver disease (NAFLD) is characterised by excessive accumulation of
hepatic lipids and oxidative injury of hepatocytes. Scutellarin is a flavonoid glycoside having …

Leaf powder supplementation of Senna alexandrina ameliorates oxidative stress, inflammation, and hepatic steatosis in high-fat diet-fed obese rats

SI Nayan, FI Chowdhury, N Akter, MM Rahman… - Plos one, 2021 - journals.plos.org
Obesity is an enduring medical issue that has raised concerns around the world. Natural
plant extracts have shown therapeutic potential in preventing oxidative stress and …

Baicalin attenuated metabolic dysfunction‐associated fatty liver disease by suppressing oxidative stress and inflammation via the p62–Keap1–Nrf2 signalling pathway …

WJ Liu, WW Chen, JY Chen, YB Sun… - Phytotherapy …, 2023 - Wiley Online Library
Metabolic dysfunction‐associated fatty liver disease (MAFLD) is the main cause of chronic
liver disease. Baicalin (Bai), a bioactive molecule found in Scutellaria baicalensis Georgi …

Scoparone improves nonalcoholic steatohepatitis through alleviating JNK/sab signaling pathway-mediated mitochondrial dysfunction

Y Jiang, J Xu, P Huang, L Yang, Y Liu, Y Li… - Frontiers in …, 2022 - frontiersin.org
The activated c-Jun N-terminal kinase (JNK) specifically combined with SH3 domain-binding
protein 5 (Sab) may mediate damage to the mitochondrial respiratory chain. Whether …