In the present study, we have investigated the anatomic distribution and the function of
different populations of HIV‐1‐and cytomegalovirus (CMV)‐specific memory CD8 T cells …

CD4 T-cell–specific memory antiviral responses to human immunodeficiency virus type 1
(HIV-1) and cytomegalovirus (CMV) were investigated in 16 patients with documented …

Abstract HIV-1-specific CD4+ T cells are qualitatively dysfunctional in the majority of HIV-1-
infected individuals and are thus unable to effectively control viral replication. The current …

The failure of human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells to control
chronic HIV-1 infection could be due to the progressive loss of their capacities to undergo …

Summary Circulating CD4+ CD8+ T lymphocytes have been described in the peripheral
blood of humans and several animal species. However, the origin and functional properties …

In vitro evidence suggests that memory CD4+ cells are preferentially infected by human
immunodeficiency virus type 1 (HIV-1), yet studies of HIV-1-infected individuals have failed …

Successful HIV vaccine strategies will likely require the induction of robust cellular immune
responses, in addition to strong humoral responses. Unfortunately, there is no clear …

We have previously reported that circulating effector cytotoxic CD8+ T-lymphocytes (CTLs)
against HIV-1 express CD38 and HLA-DR activation antigens. In this study, we performed …

ABSTRACT HIV-1-specific CD8 T cells can influence HIV-1 disease progression during
untreated HIV-1 infection, but the functional and phenotypic properties of HIV-1-specific CD8 …

ABSTRACT CD4+ T-cell help is essential for effective immune responses to viruses. In
human immunodeficiency virus (HIV) infection, CD4+ T cells specific for HIV are infected by …