Early detection and treatment are critical for improving the outcome of patients with cancer.
Understanding the largely uncharted biology of carcinogenesis requires deciphering …

The interplay between an evolving cancer and a dynamic immune microenvironment
remains unclear. Here we analyse 258 regions from 88 early-stage, untreated non-small-cell …

Macrophages have a key role in shaping the tumour microenvironment (TME), tumour
immunity and response to immunotherapy, which makes them an important target for cancer …

Before squamous cell lung cancer develops, precancerous lesions can be found in the
airways. From longitudinal monitoring, we know that only half of such lesions become …

Single-cell technologies have revealed the complexity of the tumour immune
microenvironment with unparalleled resolution,,,,,,,–. Most clinical strategies rely on …

The capacity of immunity to control and shape cancer, that is, cancer immunoediting, is the
result of three processes,,,,,,, that function either independently or in sequence: elimination …

Immunotherapies have achieved remarkable successes in the treatment of cancer, but major
challenges remain,. An inherent weakness of current treatment approaches is that …

Developmental processes underlying normal tissue regeneration have been implicated in
cancer, but the degree of their enactment during tumor progression and under the selective …

Disseminated cancer cells from primary tumours can seed in distal tissues, but may take
several years to form overt metastases, a phenomenon that is termed tumour dormancy …

Lung squamous cell carcinoma (lung SqCC) is a common type of lung cancer, causing
approximately 400,000 deaths per year worldwide. Genomic alterations in lung SqCC have …