Importance The ENIGMA clinical high risk (CHR) for psychosis initiative, the largest pooled
neuroimaging sample of individuals at CHR to date, aims to discover robust neurobiological …

Background: Several cross-sectional studies report brain structure differences between
healthy volunteers and subjects at genetic or clinical high risk of developing schizophrenia …

OBJECTIVES: In early stage psychosis research the identification of neurobiological
correlates of vulnerability to schizophrenia is an important hurdle. METHODS: We …

Background Individuals at clinical high risk (CHR) who progress to fully psychotic symptoms
have been observed to show a steeper rate of cortical gray matter reduction compared with …

Context People experiencing possible prodromal symptoms of psychosis have a very high
risk of developing the disorder, but it is not possible to predict, on the basis of their …

Background Psychotic disorders, such as schizophrenia, are associated with
neuroanatomical abnormalities, but whether these predate the onset of symptoms or …

BACKGROUND: Several studies have indicated that people with prodromal signs of
psychosis show alterations in the structure and function of the brain when they first present …

The introduction of clinical criteria for the operationalization of psychosis high risk provided a
basis for early detection and treatment of vulnerable individuals. However, about two-thirds …

To date, the MRI-based individualized prediction of psychosis has only been demonstrated
in single-site studies. It remains unclear if MRI biomarkers generalize across different …

Comorbid mental disorders in subjects at clinical high risk for psychosis (CHR-P) may
impact preventive care. We conducted a PRISMA/MOOSE-compliant systematic meta …