Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
General cognitive function is a prominent and relatively stable human trait that is associated
with many important life outcomes. We combine cognitive and genetic data from the …
with many important life outcomes. We combine cognitive and genetic data from the …
Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N= 53 949)
General cognitive function is substantially heritable across the human life course from
adolescence to old age. We investigated the genetic contribution to variation in this …
adolescence to old age. We investigated the genetic contribution to variation in this …
Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N= 112 151)
People's differences in cognitive functions are partly heritable and are associated with
important life outcomes. Previous genome-wide association (GWA) studies of cognitive …
important life outcomes. Previous genome-wide association (GWA) studies of cognitive …
[HTML][HTML] Age-dependent pleiotropy between general cognitive function and major psychiatric disorders
Background General cognitive function predicts psychiatric illness across the life course.
This study examines the role of pleiotropy in explaining the link between cognitive function …
This study examines the role of pleiotropy in explaining the link between cognitive function …
GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium
JW Trampush, MLZ Yang, J Yu, E Knowles… - Molecular …, 2017 - nature.com
The complex nature of human cognition has resulted in cognitive genomics lagging behind
many other fields in terms of gene discovery using genome-wide association study (GWAS) …
many other fields in terms of gene discovery using genome-wide association study (GWAS) …
The impact of rare protein coding genetic variation on adult cognitive function
Compelling evidence suggests that human cognitive function is strongly influenced by
genetics. Here, we conduct a large-scale exome study to examine whether rare protein …
genetics. Here, we conduct a large-scale exome study to examine whether rare protein …
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence
Intelligence is highly heritable and a major determinant of human health and well-being.
Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in …
Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in …
Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N= 112 151) and 24 GWAS consortia
Causes of the well-documented association between low levels of cognitive functioning and
many adverse neuropsychiatric outcomes, poorer physical health and earlier death remain …
many adverse neuropsychiatric outcomes, poorer physical health and earlier death remain …
A general dimension of genetic sharing across diverse cognitive traits inferred from molecular data
It has been known since 1904 that, in humans, diverse cognitive traits are positively
intercorrelated. This forms the basis for the general factor of intelligence (g). Here, we …
intercorrelated. This forms the basis for the general factor of intelligence (g). Here, we …
A three-stage genome-wide association study of general cognitive ability: hunting the small effects
Childhood general cognitive ability (g) is important for a wide range of outcomes in later life,
from school achievement to occupational success and life expectancy. Large-scale …
from school achievement to occupational success and life expectancy. Large-scale …