Neurodegeneration in multiple sclerosis (MS) is believed to underlie disease progression
and permanent disability. Many mechanisms of neurodegeneration in MS have been …

A healthy physiological environment of cells represents the dynamic homeostasis of
crowded molecules. A subset of cellular proteome forms protein quality control (PQC) …

Myelin basic protein (MBP) is a family of developmentally-regulated and translocatable
isoforms involved in formation of the myelin sheath of the central nervous system …

Trans-synaptic interactions involving Neurexins and Neuroligins are thought to promote
adhesive interactions for precise alignment of the pre-and postsynaptic compartments and …

Myelination in the central nervous system provides a unique example of how cells establish
asymmetry. The myelinating cell, the oligodendrocyte, extends processes to and wraps …

Remyelination is a central aspect of new multiple sclerosis (MS) therapies, in which one
aims to alleviate disease symptoms by improving axonal protection. However, a central …

In the developing peripheral nervous system, a coordinated reciprocal signaling between
Schwann cells and axons is crucial for accurate myelination. The myelin and lymphocyte …

Altered cellular localization and pathologic aggregation of RNA binding proteins (RPBs)
containing low complexity regions (LCRs) is a hallmark of neurodegenerative diseases such …

The aggregation of RNA-binding proteins is a pathological hallmark of amyotrophic lateral
sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). RBM45 is an RNA-binding …

Dementia is a syndrome associated with a wide range of clinical features including
progressive cognitive decline and patient inability to self-care. Due to rapidly increasing …