Neurodegeneration in the adult mammalian central nervous system (CNS) is fundamentally
accelerated by its intrinsic neuronal mechanisms, including its poor regenerative capacity …

Several neurodegenerative diseases are characterized by the accumulation of aggregated
misfolded proteins. These pathological agents have been suggested to propagate in the …

Highlights•The Gpr126 and Neuregulin 1 pathways coordinately regulate the initiation of
myelination.•Different mechanisms regulate the initiation, maturation, and maintenance of …

Motor neuron diseases (MNDs) are fatal diseases characterized by loss of motor neurons in
the brain cortex, in the bulbar region, and/or in the anterior horns of the spinal cord. While …

The myelin sheath insulates axons and allows for rapid salutatory conduction in the nervous
system of all vertebrates. The formation of peripheral myelin requires expression of the …

A large fraction of the human genome encodes intrinsically disordered proteins/regions
(IDPs/IDRs) that are involved in diverse cellular functions/regulation and dysfunctions …

Myelin sheath thickness is precisely adjusted to axon caliber, and in the peripheral nervous
system, neuregulin 1 (NRG1) type III is a key regulator of this process. It has been proposed …

The intrinsically disordered 18.5 kDa classic isoform of MBP (myelin basic protein) interacts
with Fyn kinase during oligodendrocyte development and myelination. It does so primarily …

Increasing studies have demonstrated multiple signaling molecules responsible for
oligodendrocytes and Schwann cells development such as migration, differentiation …

Proper homeostasis of the proteome, referred to as proteostasis, is maintained by
chaperone-dependent refolding of misfolded proteins and by protein degradation via the …