Endoplasmic reticulum (ER) stress has been extensively described in many protein
misfolding disorders including amyotrophic lateral sclerosis (ALS). Adaptation to ER stress is …

During development of the peripheral nervous system in mammals, Schwann cells wrap
their plasma membranes around neuronal axons, forming multiple myelin sheaths. A mature …

Multiple neurodegenerative diseases (NDDs) such as Alzheimer's disease (AD), Parkinson's
disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington's disease (HD) are being …

Background Although there is a range of different symptoms across neurodegenerative
diseases, they have been noted to have common pathogenic features. An archetypal feature …

Mammalian cells remove misfolded proteins using various proteolytic systems, including the
ubiquitin (Ub)-proteasome system (UPS), chaperone mediated autophagy (CMA) and …

Approximately 70 human RNA-binding proteins (RBPs) contain a prion-like domain (PrLD).
PrLDs are low-complexity domains that possess a similar amino acid composition to prion …

Protein associated with Myc (PAM) is a giant E3 ubiquitin ligase of 510 kDa. Although the
role of PAM during neuronal development is well established, very little is known about its …

Neurodegenerative diseases, including Alzheimer's Disease (AD), Parkinson's Disease
(PD), Amyotrophic Lateral Sclerosis (ALS) and Huntington's Disease (HD), are characterized …

Traditionally, myelin is viewed as insulation around axons, however, more recent studies
have shown it also plays an important role in plasticity, axonal metabolism, and …

Understanding networks of interacting proteins is a major goal in cell biology. The survival of
motor neurons protein (SMN) interacts, directly or indirectly, with a large number of other …