Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative condition, most widely
characterized by the selective vulnerability of motor neurons and the poor life expectancy of …

Objective Amyotrophic lateral sclerosis (ALS) is a complex disease with numerous
pathological mechanisms resulting in a heterogeneous patient population. Using …

Objective To evaluate the classifier performance, clinical and biochemical correlations of
cerebrospinal fluid (CSF) levels of the chitinase proteins Chitotriosidase-1 (CHIT1) …

Objective To evaluate the CSF levels of chitinase proteins during the presymptomatic and
early symptomatic phases of amyotrophic lateral sclerosis (ALS). Methods CSF samples …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative neuromuscular disease that
affects motor neurons controlling voluntary muscles. Survival is usually 2–5 years after …

Neuroinflammation significantly contributes to Amyotrophic Lateral Sclerosis (ALS)
pathology. In lieu of this, reports of elevated chitinase levels in ALS are interesting, as they …

Objective The neurodegenerative disease, amyotrophic lateral sclerosis (ALS), is a
heterogeneous clinical syndrome involving multiple molecular pathways. The development …

Objective: Levels of chitotriosidase (CHIT1) are increased in the cerebrospinal fluid (CSF) of
amyotrophic lateral sclerosis (ALS) patients reflecting microglial activation. Here, we …

Background: The development of biomarkers for use in diagnosing, monitoring disease
progression and analyzing therapeutic trials response in amyotrophic lateral sclerosis (ALS) …

The aim of this study was to determine if blood chitotriosidase (Chit) activity and lysosomal
enzyme levels might represent markers of disease activity and progression in amyotrophic …