The roles of TRPV1, TRPA1 and TRPM8 channels in chemical and thermal sensitivity of the mouse oral mucosa

TI Kichko, W Neuhuber, G Kobal… - European Journal of …, 2018 - Wiley Online Library
Spices in food and beverages and compounds in tobacco smoke interact with sensory
irritant receptors of the transient receptor potential (TRP) cation channel family. TRPV 1 …

Involvement of transient receptor potential A1 channel in algesic and analgesic actions of the organic compound limonene

T Kaimoto, Y Hatakeyama, K Takahashi… - … Journal of Pain, 2016 - Wiley Online Library
Background TRPA 1 is a Ca‐permeable nonselective cation channel expressed in sensory
neurons and acts as a nocisensor. Recent reports show that some monoterpenes, a group of …

[HTML][HTML] High-concentration L-menthol exhibits counter-irritancy to neurogenic inflammation, thermal and mechanical hyperalgesia caused by trans-cinnamaldehyde

HH Andersen, P Gazerani, L Arendt-Nielsen - The Journal of Pain, 2016 - Elsevier
The transient receptor potential cation channel subfamily M 8 (TRPM8) agonist L-menthol
has been used traditionally for its topical counterirritant properties. Although the use of …

Isopentenyl pyrophosphate is a novel antinociceptive substance that inhibits TRPV3 and TRPA1 ion channels

S Bang, S Yoo, TJ Yang, H Cho, SW Hwang - Pain, 2011 - journals.lww.com
Transient receptor potential ion channels (TRPs) expressed in the periphery sense and
electrically transduce noxious stimuli to transmit the signals to the brain. Many natural and …

Identification of a partial and selective TRPV1 agonist CPIPC for alleviation of inflammatory pain

L Dong, Q Zhou, Q Liang, Z Qiao, Y Liu, L Shao… - Molecules, 2022 - mdpi.com
Transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel,
predominantly expressed in a subset of peripheral sensory neurons for pain signaling …

Acute and neuropathic orofacial antinociceptive effect of eucalyptol

JMA Melo Júnior, MBMV Damasceno… - …, 2017 - Springer
Terpenes have a wide range of pharmacological properties, including antinociceptive
action. The anti-inflammatory and antinociceptive effects of eucalyptol are well established …

Orofacial anti-hypernociceptive effect of citral in acute and persistent inflammatory models in rats

BM Santos, WS Santos, IG Solon, FS Garcia… - Archives of Oral …, 2023 - Elsevier
Orofacial pain has significant psychological and physiological effects. Citral (3, 7-dimethyl-2,
6-octadienal) is the main component of Cymbopogon citratus (DC) Stapf, an herb with …

Niflumic acid, a TRPV1 channel modulator, ameliorates stavudine-induced neuropathic pain

L Marwaha, Y Bansal, R Singh, P Saroj, RK Sodhi… - …, 2016 - Springer
TRP channels have been discovered as a specialized group of somatosensory neurons
involved in the detection of noxious stimuli. Desensitization of TRPV1 located on dorsal root …

Effects of an intrathecal TRPV1 antagonist, SB366791, on morphine-induced itch, body temperature, and antinociception in mice

S Sakakibara, N Imamachi, M Sakakihara… - Journal of Pain …, 2019 - Taylor & Francis
Purpose Transient receptor potential vanilloid 1 (TRPV1) not only is activated by multiple
stimuli but also is involved with histamine-induced itch. The effects of TRPV1 on morphine …

Pronociceptive response elicited by TRPA1 receptor activation in mice

EL Andrade, AP Luiz, J Ferreira, JB Calixto - Neuroscience, 2008 - Elsevier
Ankyrin-repeat transient receptor potential 1 (TRPA1) is a member of the transient receptor
potential (TRP) channel family and it is found in sensory neurons. In the present study, we …