Background Chronic orofacial pain is a serious public health problem with a prevalence of 7–
11% in the population. This disorder has different etiologies and characteristics that make …

Currently used analgesics have several side effects urging the need for new natural sources
of therapeutics. Transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation …

Trigeminal neuropathic pain (TNP) is often resistant to current pharmacotherapy, and there
is a pressing need to develop more efficacious treatments. Capsaicin is a pungent …

Capsaicin is a naturally occurring vanilloid that causes a hot, pungent sensation in the
human oral cavity. This trigeminal stimulus activates TRPV1 receptors and stimulates an …

Transient receptor potential vanilloid 1 (TRPV1) is a Ca 2+-permeable non-selective cation
channel that transmits pain signals. TRPV1 is activated by multiple stimuli such as capsaicin …

This study aimed to evaluate the antinociceptive effect of oleanolic acid using adult zebrafish
models of orofacial pain. Acute nociception was induced by formalin, capsaicin …

The transient receptor potential vanilloid 1 (TRPV1) receptor is relevant to the perception of
noxious information and has been studied as a therapeutic target for the development of …

Aims Extensive evidence supports a role for voltage-gated calcium channels (VGCC) and
TRPV1 receptors in pain transmission and modulation. We investigated the profile of …

We previously showed that magnesium sulfate (MS) has systemic antinociceptive and local
peripheral pronociceptive effects. The role of transient receptor potential (TRP) channels …

Clotrimazole (CLT) is a widely used drug for the topical treatment of yeast infections of skin,
vagina, and mouth. Common side effects of topical CLT application include irritation and …