Cancer stem cells (CSCs) show a self-renewal capacity and differentiation potential that
contribute to tumor progression and therapy resistance. However, the underlying processes …

Simple Summary Cancer is one of the hardest pathologies to fight, being one of the main
causes of death worldwide despite the constant development of novel therapeutic strategies …

Cancer stem cells (CSCs), initially identified in leukemia in 1994, constitute a distinct subset
of tumor cells characterized by surface markers such as CD133, CD44, and ALDH. Their …

Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Unlike other normal cells, a subpopulation of cells often termed as “stem cells” are long-lived
and generate cellular progeny throughout life. Cancer stem cells (CSCs) are rare immortal …

The study of cancer stem cells (CSCs) has shown that tumors are driven by a subpopulation
of self-renewing CSCs that retain the capacity to engender the various differentiated cell …

Therapy resistance is a major problem when treating cancer patients as cancer cells
develop mechanisms that counteract the effect of therapeutic compounds, leading to fit and …

Resistance to chemotherapy and cancer relapse are major clinical challenges attributed to a
sub population of cancer stem cells (CSCs). The concept of CSCs has been the subject of …

Chemoresistant metastatic relapse of minimal residual disease plays a significant role for
poor prognosis of cancer. Growing evidence supports a critical role of cancer stem cell …

Notwithstanding cancer patients benefit from a plethora of therapeutic alternatives, drug
resistance remains a critical hurdle. Indeed, the high mortality rate is associated with …