Mitochondria quality control and male fertility

J Costa, PC Braga, I Rebelo, PF Oliveira, MG Alves - Biology, 2023 - mdpi.com
Simple Summary Mitochondria play a crucial role in numerous cellular processes, including
energy production, apoptosis, and calcium homeostasis. In the male reproductive system …

Mitochondrial functionality in male fertility: from spermatogenesis to fertilization

YJ Park, MG Pang - Antioxidants, 2021 - mdpi.com
Mitochondria are structurally and functionally distinct organelles that produce adenosine
triphosphate (ATP) through oxidative phosphorylation (OXPHOS), to provide energy to …

Age-related decline of male fertility: mitochondrial dysfunction and the antioxidant interventions

JJ Wang, SX Wang, Tehmina, Y Feng, RF Zhang… - Pharmaceuticals, 2022 - mdpi.com
Mitochondria are structurally and functionally unique organelles in male gametes.
Apparently, as the only organelles remaining in mature sperm, mitochondria not only …

Mitochondria functionality and sperm quality

A Amaral, B Lourenço, M Marques… - …, 2013 - rep.bioscientifica.com
Although mitochondria are best known for being the eukaryotic cell powerhouses, these
organelles participate in various cellular functions besides ATP production, such as calcium …

Causes and consequences of sperm mitochondrial dysfunction

D Durairajanayagam, D Singh, A Agarwal… - Andrologia, 2021 - Wiley Online Library
Mitochondria have multiple functions, including synthesis of adenine triphosphate,
production of reactive oxygen species, calcium signalling, thermogenesis and apoptosis …

Mitochondrial reactive oxygen species (ROS) production alters sperm quality

R Chianese, R Pierantoni - Antioxidants, 2021 - mdpi.com
Besides ATP production, mitochondria are key organelles in several cellular functions, such
as steroid hormone biosynthesis, calcium homoeostasis, intrinsic apoptotic pathway, and the …

Mitochondrial functionality in reproduction: from gonads and gametes to embryos and embryonic stem cells

J Ramalho-Santos, S Varum, S Amaral… - Human reproduction …, 2009 - academic.oup.com
BACKGROUND Mitochondria are multitasking organelles involved in ATP synthesis,
reactive oxygen species (ROS) production, calcium signalling and apoptosis; and …

[HTML][HTML] Mitochondrial metabolism determines the functional status of human sperm and correlates with semen parameters

P Irigoyen, P Pintos-Polasky… - Frontiers in Cell and …, 2022 - frontiersin.org
The diagnosis of male infertility is based essentially on the patient's medical history and a
standard semen analysis. However, the latter rarely provides information on the causes of a …

Mitochondria, spermatogenesis and male infertility

S Rajender, P Rahul, AA Mahdi - Mitochondrion, 2010 - Elsevier
Mitochondria and its role in male reproduction has remained an enigma since long.
Similarly, etiology of male infertility in a large percentage of individuals, mainly primary …

Pathophysiology of mitochondrial dysfunction in human spermatozoa: focus on energetic metabolism, oxidative stress and apoptosis

C Castellini, S D'Andrea, G Cordeschi, M Totaro… - Antioxidants, 2021 - mdpi.com
The dogma of mitochondria as the major source of energy in supporting sperm motility
should be critically reconsidered in the light of several experimental data pointing to a major …