Exosome miR-223-3p in the bone marrow-derived mesenchymal stem cells alleviates the inflammation and airway remodeling through NLRP3-induced ASC/Caspase …

X Li, N Yang - International Immunopharmacology, 2023 - Elsevier
Asthma is one of the most common chronic respiratory diseases in the world. Exploration
and understanding of the pathogenesis of epithelial-mesenchymal transition in airway …

[HTML][HTML] Therapeutic potential of human stem cell-derived extracellular vesicles in idiopathic pulmonary fibrosis

KS Lee, SH Yeom, MK Kim, CH Woo, YC Choi… - Extracellular …, 2024 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a lethal and chronic lung disease that occurs due to
persistent epithelial cell injury and abnormal extracellular matrix (ECM) deposition …

[HTML][HTML] Mesenchymal stem cell-derived exosomes as delivery vehicles for non-coding RNAs in lung diseases

Y Feng, K Guo, J Jiang, S Lin - Biomedicine & Pharmacotherapy, 2024 - Elsevier
The burden of lung diseases is gradually increasing with an increase in the average human
life expectancy. Therefore, it is necessary to identify effective methods to treat lung diseases …

Mouse mesenchymal stem cell-derived exosomal miR-466f-3p reverses EMT process through inhibiting AKT/GSK3β pathway via c-MET in radiation-induced lung …

Y Li, Z Shen, X Jiang, Y Wang, Z Yang, Y Mao… - Journal of Experimental …, 2022 - Springer
Background Radiation-induced lung fibrosis (RILF) is a common complication of thoracic
radiotherapy. Alveolar epithelial cells play a crucial role in lung fibrosis via epithelial …

[HTML][HTML] Profibrogenic macrophage-targeted delivery of mitochondrial protector via exosome formula for alleviating pulmonary fibrosis

W Zhang, Z Wan, D Qu, W Sun, L Zhang, Y Liang… - Bioactive Materials, 2024 - Elsevier
Pulmonary fibrosis (PF) is a devastating lung disease with limited treatment options. During
this pathological process, the profibrogenic macrophage subpopulation plays a crucial role …

HDAC8-inhibitor PCI-34051-induced exosomes inhibit human bronchial smooth muscle cell proliferation via miR-381-3p mediated TGFB3

SY Bai, ML Li, Y Ren, XM Su - Pulmonary Pharmacology & Therapeutics, 2021 - Elsevier
The present study aimed to investigate the effects of PCI-34051-induced human bronchial
epithelial cells (HBECs)-derived exosomes (PCI-Exo) on human bronchial smooth muscle …

microRNA-130b-3p contained in MSC-derived EVs promotes lung cancer progression by regulating the FOXO3/NFE2L2/TXNRD1 axis

Q Guo, J Yan, T Song, C Zhong, J Kuang, Y Mo… - Molecular Therapy …, 2021 - cell.com
This study aimed to explore the molecular mechanism by which mesenchymal stem cells
(MSCs) mediate lung cancer progression. Extracellular vesicles (EVs) were isolated from …

microRNA-204 shuttled by mesenchymal stem cell-derived exosomes inhibits the migration and invasion of non-small-cell lung cancer cells via the KLF7/AKT/HIF-1α …

LIU Xiao-Ni, CB Zhang, LIN Hai, T Xiao-Yuan… - …, 2021 - search.ebscohost.com
Non-small-cell lung cancer (NSCLC) remains the leading cause of cancer-related death
worldwide. Accumulating researches have highlighted the ability of exosome-encapsulated …

Mesenchymal stromal cells-derived exosomes alleviate ischemia/reperfusion injury in mouse lung by transporting anti-apoptotic miR-21-5p

J wei Li, L Wei, Z Han, Z Chen - European Journal of Pharmacology, 2019 - Elsevier
Abstract MiR-21-5p is an anti-apoptotic miRNA known to mediate the protective effect of
mesenchymal stromal cell-secreted exosomes (MSC-Exo) against oxidative stress-induced …

Exosome-mediated microRNA-497 delivery for anti-cancer therapy in a microfluidic 3D lung cancer model

K Jeong, YJ Yu, JY You, WJ Rhee, JA Kim - Lab on a Chip, 2020 - pubs.rsc.org
Non-small cell lung cancer (NSCLC) is one of the leading causes of death from cancer
worldwide. The delivery and controlled regulation of miRNAs via exosomes is known as a …