Targeting neutrophils in inflammatory bowel disease: revisiting the role of adsorptive granulocyte and monocyte apheresis

G Bamias, E Zampeli, E Domènech - Expert Review of …, 2022 - Taylor & Francis
Introduction Inflammatory bowel disease (IBD) is a chronic immune-mediated disease of the
gastrointestinal tract comprising Crohn's disease (CD) and ulcerative colitis (UC). While any …

Therapeutic leukocytapheresis for inflammatory bowel disease

AR Saniabadi, H Hanai, K Fukunaga, K Sawada… - … and Apheresis Science, 2007 - Elsevier
The inference that granulocytes and monocytes/macrophages (GM) are part of the
immunopathogenesis of inflammatory bowel disease (IBD) and hence should be targets of …

The mode of actions of the Adacolumn therapeutic leucocytapheresis in patients with inflammatory bowel disease: a concise review

H Hanai, Y Takeda, M Eberhardson… - Clinical & …, 2011 - academic.oup.com
Patients with active inflammatory bowel disease (IBD) have elevated and activated myeloid
leucocytes which infiltrate the colonic mucosa in vast numbers. Myeloid leucocytes such as …

[HTML][HTML] Treating inflammatory bowel disease by adsorptive leucocytapheresis: a desire to treat without drugs

AR Saniabadi, T Tanaka, T Ohmori… - World Journal of …, 2014 - ncbi.nlm.nih.gov
Ulcerative colitis and Crohn's disease are the major phenotypes of the idiopathic
inflammatory bowel disease (IBD), which afflicts millions of individuals throughout the world …

[HTML][HTML] Selective granulocyte and monocyte apheresis in inflammatory bowel disease: Its past, present and future

XL Chen, JW Mao, YD Wang - World Journal of Gastrointestinal …, 2020 - ncbi.nlm.nih.gov
The etiology and pathogenesis of inflammatory bowel disease (IBD), including ulcerative
colitis and Crohn's disease, are not fully understood so far. Therefore, IBD still remains …

Granulomonocytapheresis as a cell‐dependent treatment option for patients with inflammatory bowel disease: concepts and clinical features for better therapeutic …

AR Saniabadi, T Tanaka, T Yamamoto… - Journal of clinical …, 2019 - Wiley Online Library
Ulcerative colitis (UC) and Crohn's disease (CD) are major phenotypes of the chronic
inflammatory bowel disease (IBD), which afflicts millions of individuals throughout the world …

[HTML][HTML] Positions of selective leukocytapheresis in the medical therapy of ulcerative colitis

H Hanai - World Journal of Gastroenterology: WJG, 2006 - ncbi.nlm.nih.gov
Ulcerative colitis (UC) and Crohn's disease (CD) are the major forms of idiopathic
inflammatory bowel disease (IBD). Both UC and CD are debilitating chronic disorders that …

Immunological mechanisms of adsorptive cytapheresis in inflammatory bowel disease

E Sáez-González, I Moret, D Alvarez-Sotomayor… - Digestive Diseases and …, 2017 - Springer
Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease
(IBD). The study of immunological pathways involved in the onset of IBD is of fundamental …

Adacolumn leucocytapheresis for ulcerative colitis: clinical and endoscopic features of responders and unresponders

R Sacco, T Tanaka, T Yamamoto, G Bresci… - Expert Review of …, 2015 - Taylor & Francis
Cytokines such as TNF-α have a validated role in the immunopathogensis of ulcerative
colitis (UC), and intercepting inflammatory cytokines is currently the best option for …

Systematic review: granulocyte/monocyte adsorptive apheresis for ulcerative colitis

S Thanaraj, PJ Hamlin, AC Ford - Alimentary pharmacology & …, 2010 - Wiley Online Library
Aliment Pharmacol Ther 2010; 32: 1297–1306 Summary Background Patients with
ulcerative colitis (UC) that is chronically active despite 5‐aminosalicylates or …