A novel estrogen receptor GPER mediates proliferation induced by 17β‐estradiol and selective GPER agonist G‐1 in estrogen receptor α (ERα)‐negative ovarian …

H Liu, Y Yan, H Wen, X Jiang, X Cao… - Cell Biology …, 2014 - Wiley Online Library
G protein‐coupled estrogen receptor (GPER) is recently identified as a membrane‐
associated estrogen receptor that mediates non‐genomic effects of estrogen. Our previous …

Role of GPER on proliferation, migration and invasion in ligand‐independent manner in human ovarian cancer cell line SKOV3

Y Yan, X Jiang, Y Zhao, H Wen… - Cell biochemistry and …, 2015 - Wiley Online Library
G protein‐coupled estrogen receptor (GPER) is identified as a critical estrogen receptor, in
addition to the classical estrogen receptors ERα and ERβ. In ERα‐negative ovarian cancer …

The novel estrogen receptor GPER regulates the migration and invasion of ovarian cancer cells

Y Yan, H Liu, H Wen, X Jiang, X Cao, G Zhang… - Molecular and cellular …, 2013 - Springer
G protein-coupled estrogen receptor (GPER) was identified as a new member of the
estrogen receptor family in recent years. It has become apparent that GPER mediates the …

[HTML][HTML] The putative G-protein coupled estrogen receptor agonist G-1 suppresses proliferation of ovarian and breast cancer cells in a GPER-independent manner

C Wang, X Lv, C Jiang, JS Davis - American journal of translational …, 2012 - ncbi.nlm.nih.gov
G-protein coupled estrogen receptor 1 (GPER) plays an important role in mediating estrogen
action in many different tissues under both physiological and pathological conditions. G-1 (1 …

G protein-coupled estrogen receptor (GPER) expression in endometrial adenocarcinoma and effect of agonist G-1 on growth of endometrial adenocarcinoma cell lines

M Skrzypczak, S Schüler, C Lattrich, A Ignatov… - Steroids, 2013 - Elsevier
The G protein-coupled estrogen receptor (GPER, GPR30) is suggested to be involved in non-
nuclear estrogen signaling and is expressed in a variety of hormone dependent cancer …

Role of G protein-coupled estrogen receptor in cancer progression

J Jung - Toxicological research, 2019 - Springer
Cancer is the leading cause of mortality worldwide. In cancer progression, sex hormones
and their receptors are thought to be major factors. Many studies have reported the effects of …

G protein-coupled estrogen receptor 1 (GPER-1) and agonist G-1 inhibit growth of ovarian cancer cells by activation of anti-tumoral transcriptome responses: impact of …

S Schüler-Toprak, M Skrzypczak, T Ignatov… - Journal of Cancer …, 2020 - Springer
Purpose The present study intended to further elucidate the role of G protein-coupled
estrogen receptor 1 (GPER-1) in ovarian cancer by comparing the effects of a GPER-1 …

GPER functions as a tumor suppressor in MCF-7 and SK-BR-3 breast cancer cells

C Weißenborn, T Ignatov, A Poehlmann… - Journal of cancer …, 2014 - Springer
Purpose The orphan, membrane-bound estrogen receptor (GPER) is expressed at high
levels in a large fraction of breast cancer patients, and its expression is favorable for …

[HTML][HTML] The G protein-coupled estrogen receptor 1 (GPER/GPR30) does not predict survival in patients with ovarian cancer

Z Kolkova, V Casslén, E Henic, S Ahmadi… - Journal of ovarian …, 2012 - Springer
Background Even though ovarian tumors are not generally considered estrogen-sensitive,
estrogens may still have an impact on ovarian tumor progression. The recently identified …

[HTML][HTML] Proliferation and apoptosis regulation by G protein‑coupled estrogen receptor in glioblastoma C6 cells

CE Gutiérrez‑Almeida, A Santerre… - Oncology …, 2022 - spandidos-publications.com
Glioblastoma is the most frequent primary tumor in the human brain. Glioblastoma cells
express aromatase and the classic estrogen receptors ERα and ERβ and can produce …