Background Even though ovarian tumors are not generally considered estrogen-sensitive,
estrogens may still have an impact on ovarian tumor progression. The recently identified …

The G protein-coupled estrogen receptor (GPER) is a seven-transmembrane-domain
receptor that mediates non-genomic estrogen related signaling. After ligand activation …

Glioblastoma is the most frequent primary tumor in the human brain. Glioblastoma cells
express aromatase and the classic estrogen receptors ERα and ERβ and can produce …

Estrogens play a crucial role in the regulation of physiological and pathophysiological
processes. These hormones act through specific receptors, most notably the canonical …

Glioblastoma (GB) is the most frequent primary brain tumor with a very poor prognosis. Sex
hormones are crucial players in the development of GBs. 17 β‑estradiol (E2) signaling is …

In addition to the classical oestrogen receptors, ERα and ERβ, a G protein-coupled
oestrogen receptor (GPER) has been identified that primarily mediates the rapid, non …

Although the action of estrogens has been traditionally explained by the binding to and
transactivation of the nuclear estrogen receptor (ER) α and ERβ, recently the G protein …

Using cDNA cloning strategies commonly employed for G protein-coupled receptors
(GPCR), GPCR-30 (GPR30), was isolated from mammalian cells before knowledge of its …

Background The orphan, membrane-bound estrogen receptor (GPER) is expressed at high
levels in a large fraction of breast cancer patients and its expression is favorable for patients' …

Background Estrogen signaling is mediated by estrogen receptor beta isoforms in normal
and neoplastic human testes. Recently, a G-protein-coupled-receptor (GPER) has been …