Evaluation of the virucidal effects of rosmarinic acid against enterovirus 71 infection via in vitro and in vivo study

WY Lin, YJ Yu, TR Jinn - Virology journal, 2019 - Springer
Abstract Background Although enterovirus 71 (EV71) is an important public health threat,
especially in the Asia-Pacific region, there are still no effective drugs or vaccines to treat and …

Inhibition of enterovirus 71 replication and viral 3C protease by quercetin

C Yao, C Xi, K Hu, W Gao, X Cai, J Qin, S Lv, C Du… - Virology journal, 2018 - Springer
Abstract Background Enterovirus 71 (EV71) is one of the major causative agents of hand,
foot, and mouth disease (HFMD), which is sometimes associated with severe central …

Anti-enterovirus 71 effects of chrysin and its phosphate ester

J Wang, T Zhang, J Du, S Cui, F Yang, Q Jin - PLoS One, 2014 - journals.plos.org
Enterovirus 71 (EV71) can cause severe disease and even lead to death in children, and an
effective antiviral drug is currently unavailable. The anti-EV71 effect of chrysin (5, 7 …

Anti-enterovirus 71 activities of Melissa officinalis extract and its biologically active constituent rosmarinic acid

SG Chen, YL Leu, ML Cheng, SC Ting, CC Liu… - Scientific reports, 2017 - nature.com
Abstract Enterovirus 71 (EV71) infection is endemic in the Asia-Pacific region. No specific
antiviral drug has been available to treat EV71 infection. Melissa officinalis (MO) is a …

Antiviral efficacy of flavonoids against enterovirus 71 infection in vitro and in newborn mice

W Dai, J Bi, F Li, S Wang, X Huang, X Meng, B Sun… - Viruses, 2019 - mdpi.com
Enterovirus 71 (EV71) infection is known to cause hand, foot, and mouth disease (HFMD),
which is associated with neurological complications; however, there is currently no effective …

Rheum emodin inhibits enterovirus 71 viral replication and affects the host cell cycle environment

T Zhong, LY Zhang, ZY Wang, Y Wang… - Acta Pharmacologica …, 2017 - nature.com
Abstract Human enterovirus 71 (EV71) is the primary causative agent of recent large-scale
outbreaks of hand, foot, and mouth disease (HFMD) in Asia. Currently, there are no drugs …

Identification of luteolin as enterovirus 71 and coxsackievirus A16 inhibitors through reporter viruses and cell viability-based screening

L Xu, W Su, J Jin, J Chen, X Li, X Zhang, M Sun, S Sun… - Viruses, 2014 - mdpi.com
Hand, foot and mouth disease (HFMD) is a common pediatric illness mainly caused by
infection with enterovirus 71 (EV71) and coxsackievirus A16 (CA16). The frequent HFMD …

Luteoloside Acts as 3C Protease Inhibitor of Enterovirus 71 In Vitro

Z Cao, Y Ding, Z Ke, L Cao, N Li, G Ding, Z Wang… - PLoS …, 2016 - journals.plos.org
Luteoloside is a member of the flavonoids family that exhibits several bioactivities including
anti-microbial and anti-cancer activities. However, the antiviral activity of luteoloside against …

Harmine, a small molecule derived from natural sources, inhibits enterovirus 71 replication by targeting NF-κB pathway

D Chen, X Tian, X Zou, S Xu, H Wang, N Zheng… - International …, 2018 - Elsevier
Abstract Enterovirus 71 (EV71) infection of young children can cause neurological
manifestations, which is mainly responsible for the fatality. Although a vaccine is recently …

Resveratrol inhibits enterovirus 71 replication and pro-inflammatory cytokine secretion in rhabdosarcoma cells through blocking IKKs/NF-κB signaling pathway

L Zhang, Y Li, Z Gu, Y Wang, M Shi, Y Ji, J Sun, X Xu… - PloS one, 2015 - journals.plos.org
Polydatin and resveratrol, as major active components in Polygonum cuspidatum, have anti-
inflammatory, antioxidant and antitumor functions. However, the effect and mechanism of …