Melatonin is a hormone produced by the pineal gland, predominantly at night, and plays a
pivotal role in regulating the circadian rhythm as well as a variety of biological functions …

Background Activation of the intrarenal renin–angiotensin system (RAS) plays a critical role
in the pathophysiology of chronic kidney disease (CKD) and hypertension. The circadian …

Background Activation of the intrarenal renin–angiotensin system (RAS) plays a critical role
in the pathophysiology of chronic kidney disease (CKD) and hypertension. It has been …

The renin–angiotensin system (RAS) plays a crucial role in the conservation of extracellular
volume homeostasis and blood pressure through complex molecular mechanisms [1]. The …

Background: The increasing incidence of chronic kidney disease (CKD), as a consequence
of the high prevalence of arterial hypertension and type 2 diabetes mellitus (T2DM) …

Diabetic nephropathy (DN) is a common complication of diabetes, and it is also the main
cause of chronic renal failure. Physiological/pathological changes mediated by high glucose …

The aim of the present study was to investigate the protective effects of melatonin (MLT) on
hypertension-induced renal injury and identify its mechanism of action. Twenty-four healthy …

The effect of melatonin was investigated in an angiotensin II‐dependent renovascular
hypertension model in Wistar albino rats by placing a renal artery clip (two‐kidney, one‐clip; …

Conclusion Recent studies shown that melatonin administration, attenuated oxidative stress,
inflammation, and restored renal function and structure in rats. Melatonin could be an …

Obesity is a common and complex health problem worldwide and can induce the
development of Type 2 diabetes. Chronic kidney disease (CKD) is a complication occurring …