While cerebrovascular disease can be observed in vivo using MRI, the multiplicity and
heterogeneity in the mechanisms of cerebrovascular damage impede accounting for these …

Objective Recent availability of amyloid and tau positron emission tomography (PET) has
provided us with a unique opportunity to measure the association of systemic vascular …

To determine whether white matter network disruption mediates the association between
MRI markers of cerebrovascular disease (CeVD) and cognitive impairment. Participants (n …

Cerebrovascular disease is a common comorbidity in older adults, typically assessed in
terms of white matter hyperintensities (WMHs) on MRI. While it is well known that WMHs …

Objective To determine whether vascular and neurodegenerative factors influence cognition
before clinically relevant Alzheimer disease pathology, we analyzed MRI measures and …

Most strokes are covert and observed incidentally on brain scans, but their presence
increases risk of overt stroke and dementia. Amyloid angiopathy, associated with Alzheimer …

Objective To develop, replicate, and validate an MRI-based quantitative measure of both
cerebrovascular and neurodegeneration in Alzheimer disease (AD) for clinical and …

Introduction Cerebrovascular disease (CVD) is not currently considered a core pathological
feature of Alzheimer's disease (AD), but mounting evidence suggests that concurrent CVD …

It remains unclear to what extent cerebrovascular burden relates to amyloid beta (Aβ)
deposition, neurodegeneration, and cognitive dysfunction in mixed disease populations with …

Objective To investigate the multifactorial processes underlying cognitive aging based on
the hypothesis that multiple causal pathways and mechanisms (amyloid, vascular, and …