In 1997, our laboratory used targeted gene disruption of the GH receptor (GHR) to generate
GHR knockout (GHR−/−) mice, which have been used in> 127 published studies to help …

GH receptor (GHR) gene-disrupted mice (GHR−/−) have provided countless discoveries as
to the numerous actions of GH. Many of these discoveries highlight the importance of GH in …

Growth hormone (GH)-induced signaling results in numerous effects in multiple tissues
throughout the body. Elucidation of several of these effects has come from studies observing …

In addition to its major role in the regulation of somatic growth, growth hormone (GH)
signaling has profound effects on function of various tissues in the body. However, the …

Three mouse lines with altered growth hormone (GH) signaling were used to study GH's role
in adiposity. Dwarf GH receptor knockout mice (GHR−/−) and bovine GH antagonist …

Global GH receptor–null or knockout (GHRKO) mice have been extensively studied owing to
their unique phenotype (dwarf and obese but remarkably insulin sensitive and long-lived) …

Growth hormone (GH) is a determinant of glucose homeostasis and adipose tissue (AT)
function. Using 7-month-old transgenic mice expressing the bovine growth hormone (bGH) …

Mice with a deficiency in GH function due to disruption of the GH receptor/binding protein
gene (GHR−/−) are long lived, insulin sensitive, and obese, whereas mice with excess GH …

Growth hormone, acting through its receptor (GHR), plays an important role in carbohydrate
metabolism and in promoting postnatal growth. GHR gene-deficient (GHR−/−) mice exhibit …

GH and IGF-1 are important for a variety of physiological processes including growth,
development, and aging. Mice with reduced levels of GH and IGF-1 have been shown to live …