Background: The objective of this study is to develop a new animal model based on
signaling pathways to understand the pathophysiology, therapy of depression, and to …

Depression is a major psychiatric disorder affecting nearly 21% of the world population and
imposes a substantial health burden on society. Current available antidepressants are not …

ETHNOPHARMACOLOGICAL RELEVANCE: Suanzaorenhehuan Formula (SHF) is a
Chinese herbal formula for the treatment of depression-like disorders. It contains four herbs …

Ethnopharmacological relevance An efficacious antidepressant without unwanted side
effects is need urgently at present. This study aimed to investigate whether treatment with …

Abstract Background Vaccinium bracteatum Thunb. leaves (VBL) are used in traditional
herbal medicines to treat various biological diseases. p-coumaric acid (CA), the main active …

Ingestion of specific probiotics, namely “psychobiotics”, produces psychotropic effects on
behavior and affects the hypothalamic–pituitary–adrenal axis and neurochemicals in the …

Pinelliae Rhizoma has been used traditionally as an antidepressant in Oriental medicine. In
this study, the effect of Pinelliae Rhizoma extract (PRe) on psychological stress was …

Objectives: The purpose of this study was to characterize the putative antidepressant and
antianxiolytic effects of the 70% ethanol extract of Polygala japonica (EEPJ) using animal's …

Ethnopharmacological relevance According to traditional Chinese medicine (TCM) theory
(Yi Xue Zheng Zhuan), the main factors associated with the pathogenesis of depression are …

Depression is a mental disorder that is highly prevalent in many parts of the globe and a
source of burden to patients and their families. Existing treatments for depression are far …