Substantial evidence indicates involvement of microglia/macrophages in chronic
neuropathic pain. However, the temporal-spatial features of microglial/macrophage …

There is a paucity of data on the role of microglia and neuroinflammatory processes in the
association between chronic pain and depression. The current study examined the effect of …

Traumatic spinal cord injury (SCI) results not only in motor impairment but also in chronic
central pain, which can be refractory to conventional treatment approaches. It has been …

Pain and depression are frequently co-existent in clinical practice, yet the underlying
mechanisms remain largely to be determined. Microglia activation and subsequent pro …

Activated glial cells (microglia and astroglia) in the spinal cord play a major role in mediating
enhanced pain states by releasing proinflammatory cytokines and other substances thought …

Activation of p38 mitogen‐activated protein kinase (p38) in spinal microglia is implicated in
spinal nociceptive processing. Minocycline, a tetracycline derivative, displays selective …

A growing body of evidence from both clinical and animal studies indicates that chronic
neuropathic pain is associated with comorbid affective disorders. Spinal cord microglial …

Some recent evidence suggests that microglia activation and inflammatory cytokine
production in the hippocampus are associated with the development of pain behavior …

Recent studies have indicated that minocycline, a microglia inhibitor, could potentially be
used as an antinociceptive agent in pain management, although the underlying …

Microglia can modulate spinal nociceptive transmission. Yet, their role in spinal cord
stimulation (SCS)-induced pain inhibition is unclear. Here, we examined how SCS affects …