Objective: Genetic polymorphisms can influence the chemotherapeutic response; however,
previous studies have produced conflicting results, and have failed to identify the most …

Purpose Multidrug resistance mediated by ABCB1 has been perceived to be one of the
obstacles for cancer chemotherapy. This meta-analysis was performed to verify the effect of …

Aim: To evaluate the association of ABCB1 gene polymorphisms with susceptibility to
colorectal cancer (CRC) and clinical outcomes of CRC patients with chemotherapy. Patients …

Numerous papers have reported ABCB1 polymorphisms are associated with the response
to chemotherapy of cancers. The inconclusive results call for a comprehensive analysis, for …

Background Taxane‐based chemotherapy is widely used in lung cancer. ABCB1 have a
role in the prediction of treatment response and toxicity of chemotherapy in solid tumors. In …

ATP‐binding cassette (ABC) transporter expression and genetic heterogeneity have been
implicated in response to anticancer therapy. This study characterized genetic variability of …

Background: ABC proteins are one key type of transport superfamilies which undertake
majority of drug transport, which affect the osteosarcoma response to chemotherapeutics …

Aim: To find out whether SNPs in the transporter gene ATP-binding casette B1 (ABCB1)
were related to adverse effects in colorectal cancer patients treated with 5-fluorouracil (5-FU) …

Platinum-based chemotherapy is the most common treatment for non-small cell lung cancer
(NSCLC). Expression level of drug metabolism and transport genes are correlated with …

Background. P-glycoprotein (Pgp) is a drug efflux pump that transports natural products,
including taxanes and other chemotherapeutic agents, from cells. Several frequent …