Background Standard treatment for osteosarcoma patients consists of a combination of
cisplatin, adriamycin, and methotrexate before surgical resection of the primary tumour …

Background ABCG2, also known as BCRP, is a half ATP-binding cassette (ABC) transporter
that localizes to plasma membranes. Recently, a number of studies have investigated the …

Purpose Not all patients respond well to cancer chemotherapy. One of the most important
factors contributing to treatment response (efficacy and toxicity) is genetic determinant. The …

Purpose Multiple drug resistance limits the efficacy of numerous cytotoxic drugs used in the
treatment of small cell lung cancer (SCLC). The drug efflux protein ATP-binding cassette …

The ABCB1 gene encodes a permeability glycoprotein, which is one of the most extensively
studied human adenosine-triphosphate (ATP)-dependent efflux transporters. Permeability …

Objective To investigate the association between ABCB1 polymorphisms and
chemosensitivity of paclitaxel in Chinese advanced gastric cancer (AGC) patients. Methods …

Objectives: The ATP-binding cassette (ABC) ABCG2, involved in multidrug resistance (MDR)
in cancer cells, plays an integral role in drug resistance. Single nucleotide polymorphisms …

Preventing severe irinotecan-induced adverse reactions would allow us to offer better
treatment and improve patients' quality of life. Transporters, metabolizing enzymes, and …

The influence of three high frequency ABCB1 polymorphisms (c. 1236C> T, c. 2677G> A/T,
and c. 3435C> T) and the ABCG2 c. 421C> A polymorphism on the disposition of …

Objective Irinotecan is a cytotoxic agent used widely for the treatment of solid tumors,
particularly for metastatic colorectal cancers. Treatment with this drug frequently results in …