The possible interaction between gene polymorphism and cancer risk development is a very
interesting issue. The genetic variants of the ATP-binding cassette superfamily B member 1 …

The genetic variants of the ATP‐binding cassette, subfamily G, member 2 (ABCG2) are
known to be involved in developing cancer risk and interindividual differences in …

Genetic polymorphisms in drug metabolism and transport genes can influence the
pharmacokinetics and pharmacodynamics of chemotherapy drugs. We investigated the role …

The ABCB1 gene belongs to ATP binding cassette (ABC) transporter genes that has been
previously implicated in cancer progression and drug response. This study aimed to …

Abstract ABCG2, CD133 and CD117 are pivotal markers of cancer stem cell, which are
involved in carcinogenesis and cancer progression. The expression of these genes has …

Among patients treated with irinotecan, homozygous carriers of the UGT1A1* 28 allele are at
increased risk for neutropenia, but UGT1A1 genotype alone does not account for irinotecan …

The prognosis of lung cancer patients treated with chemotherapy is poor, motivating the
search for predictive factors. Single nucleotide polymorphisms (SNPs) in membrane …

Purpose Capecitabine is a prodrug that converts to 5-fluorouracil (5-FU) in three steps. A
previous study showed that ABCA2 rs2271862 (C> T) and ABCG5 rs6720173 were …

In a previous in vitro study, we showed that the Arg723Gln (2168G> A) polymorphism
significantly ABCC1‐induced multidrug resistance. The aim of the present study was to …

2009 Background: Irinotecan unexpectedly causes severe, occasionally fatal, toxicity of
leukopenia or diarrhea. Irinotecan is metabolized by carboxylesterase to form an active SN …