Esophageal cancer is a common cause of death from cancer in men and the eighth most
prevalent cancer globally. The morbidity and mortality rates are four times higher in men …

Resistance to antiemetic treatment with 5-hydroxytryptamine-3 receptor antagonist is an
issue. This study evaluated the potential roles of ABCB1 and ABCG2 polymorphisms in …

Background The accumulation of mutagenic substances in the human body may result in
DNA metabolism disruption followed by carcinogenesis. As a consequence of mutations in …

Overexpression of the multi-drug transporter P-glycoprotein, encoded by the ABCB1 gene, is
a clinically relevant problem in acute myeloid leukemia (AML). Polymorphisms in ABCB1 …

Background Gefitinib is frequently used to treat patients with non-small cell lung cancer
(NSCLC) and is excreted out from cells via the ATP-binding cassette transporter ABCG2 …

Background: Amrubicin is a promising therapy for lung cancer, but is associated with a high
incidence of severe neutropenia. The present study assessed the utility of ABCB1 and NAD …

Background: One of the major mechanisms for drug resistance is associated with altered
anticancer drug transport, mediated by the human-adenosine triphosphate binding cassette …

Objective Multiple factors are involved in oxaliplatin-resistant process in colorectal cancer
(CRC) patients including decreased drug accumulation and enhanced capacity to repair …

Objectives ATP-Binding Cassette (ABC) transporters may cause treatment failure by
transporting of anticancer drugs outside of the tumor cells. Multidrug resistance-associated …

Purpose Dose-limiting toxicities of docetaxel are widely considered to be neutropenia,
anemia, skin toxicity, and nausea. One of the factors that limit the use of docetaxel is its …